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Iverhart Plus

Iverhart Plus by Virbac

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Iverhart Plus for dogs is a heartworm preventative that also controls roundworms and hookworms. Iverhart Plus (ivermectin/pyrantel) is a generic equivalent to Heartgard Plus.

Dogs can be born with genetic mutations that impact their health. One such mutation is the MDR1 gene mutation. The MDR1 (multi-drug resistance-1) gene is responsible for the production of P-glycoprotein, which is normally responsible for transporting certain drugs out of the brain. The MDR1 gene mutation is generally found in many herding breeds, some sighthound breeds and many mixed-breed dogs.

Dogs that have a mutation in the MDR1 gene, which inhibits their ability to remove certain drugs from the brain and can lead up to a buildup of toxins, may have severe adverse reactions to some common drugs, including seizures, tremors, disorientation, blindness, lack of muscle control or even death.

Which breeds are affected?

  • Australian Shepherd  
  • Border Collie
  • Collie
  • English Shepherd
  • German Shepherd
  • Long-Haired Whippet
  • McNab
  • Miniature Australian Shepherd
  • Mixed Breed  
  • Old English Sheepdog
  • Shetland Sheepdog
  • Silken Windhound



MDR1 is the abbreviated name of a gene called Multi-Drug Resistance 1. A mutation of this gene causes sensitivity to Ivermectin and a number of other drugs. Dogs with the mutation will react to those drugs.

MDR1 : Multidrug Resistance 1 is inherited as an autosomal incomplete dominant disease. Dogs only need to inherit one copy of the MDR1 mutation to be at risk for sensitivity of certain drugs. Dogs with 2 copies of MDR1 can have more severe reactions.

Please speak with your veterinarian about testing for MDR1 if you own a breed of dog which may have MDR1 gene.

(Tri­Heart Plus, Heartgard, Heartgard Plus, Iverhart Plus)

Common Drug Name

Common Brand Names
Single Ingredient Products
Heartgard Chewables for Dogs Heartgard Chewables for Cats

Combination Products
Heartgard Plus Chewables for Dogs, Tri­Heart Plus (for dogs), Iverhart Plus (for dogs) contain ivermectin and pyrantel pamoate

Store at room temperature in a tightly closed container, protected from light.

Dogs: Ivermectin is used as a heartworm preventive. Products with pyrantel pamoate are also used for the treatment and control of roundworms and hookworms.
Cats: Ivermectin is used as a heartworm preventive and for the removal and control of hookworms.
Ferrets: Ivermectin is used as a heartworm preventive.
Do NOT use in turtles.

Dose and Administration
Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.
Follow your veterinarian?s directions on when to give this medication. If advised to give it seasonally, remember to give it during and 1 month beyond the mosquito season, preferably on the same date each month. The tablet kills the parasites acquired during the previous month. (The tablet given May 1st treats exposures to heartworm during the month of April.)
If a dose is missed, give the tablet imme­diately and resume giving a tablet every 30 days (once a month). Contact your veterinarian regarding the need to have your pet heartworm tested in 6­7 months.
Heartgard Chewable tablets should be chewed. If you think your pet will swallow them whole, break them into pieces before giving them. Tri­Heart Plus and Iverhart Plus chewable tablets will be equally effective whether chewed or swallowed whole.
If switching from diethylcarbamazine (a once­a­day heartworm preventive) give ivermectin within 30 days of discontinuing the diethylcarbamazine.
This medication should only be given to the pet for whom it was prescribed.

Possible Side Effects
Side effects are rare at the recommended heartworm prevention dosage.
If your pet experiences an allergic reaction to the medication or to dying parasites, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Not for use in animals who are hypersensitive (allergic) to it.
Studies support the safety of ivermectin products in dogs, including Collies, when used as recommended by the label.
Do not use in puppies or kittens less than 6 weeks of age.
Considered to be safe to use in pregnant and lactating animals (female animals nursing their young).
Consult with your veterinarian regarding necessary physical examinations and heartworm testing necessary prior to and during treatment with heartworm medications.
Some intestinal parasites may be zoonotic (able to infect humans). Ask your veter­inarian or physician how to prevent human infection and reinfection of your pet.
Properly dispose of unused ivermectin, as it may be toxic to fish and other animals.

Drug, Food, and Test Interactions
Although there are no known drug or food interactions with this medication, consult with your veterinarian before using ivermectin with any other medications, including vitamins and supplements, since interactions may occur.

Signs of Toxicity/Overdose
Dogs: May see staggering, vomiting, diarrhea, depression, or dilated pupils.
Cats: May see agitation, vocalization, loss of appetite, dilation of pupils, staggering, tremors, blindness, head­pressing, wall­climbing, and disorientation.
Most animals recover in 2­4 weeks with supportive care. If you know or suspect your pet has had an overdose, or if you observe any of these signs, contact your veterinarian immediately.
Keep this and all other medications out of the reach of children and pets.

This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times. Always consult your own veterinarian for specific advice concerning the treatment of your pet.


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