HEARTGARD® Plus Chewables for Dogs
Heartgard's Generic Name:
Ivermectin + Pyrantel pamoate
Ivermectin + pyrantel pamoate is a combination of 2 anti-parasitic drugs used monthly in dogs and cats to prevent heartworm infection and for the treatment and control of roundworms and hookworms. This product may be given with or without food. Chewable tablets are available in different strengths.
- Ivermectin and pyrantel pamoate is a combination of two anti-parasite drugs
- Ivermectin and pyrantel pamoate is given by mouth
- For heartworm prevention in dogs
- For treatment and control of roundworms and hookworms
- For use in dogs only
- Puppies less than 6 weeks of age
- Safe for use in Collies, Australian shepherds, Old English sheepdogs, Shelties and any of these crossbreed dogs if given the regular monthly heartworm preventative dosing level
- Safe for use in breeding, pregnant and nursing animals
- Pets known to have had an allergic reaction to ivermectin or pyrantel pamoate or like products
Dogs can be born with genetic mutations that impact their health. One such mutation is the MDR1 gene mutation. The MDR1 (multi-drug resistance-1) gene is responsible for the production of P-glycoprotein, which is normally responsible for transporting certain drugs out of the brain. The MDR1 gene mutation is generally found in many herding breeds, some sighthound breeds and many mixed-breed dogs.
Dogs that have a mutation in the MDR1 gene, which inhibits their ability to remove certain drugs from the brain and can lead up to a buildup of toxins, may have severe adverse reactions to some common drugs, including seizures, tremors, disorientation, blindness, lack of muscle control or even death.
Which breeds are affected?
- Australian Shepherd
- Border Collie
- English Shepherd
- German Shepherd
- Long-Haired Whippet
- Miniature Australian Shepherd
- Mixed Breed
- Old English Sheepdog
- Shetland Sheepdog
- Silken Windhound
MDR1 is the abbreviated name of a gene called Multi-Drug Resistance 1. A mutation of this gene causes sensitivity to Ivermectin and a number of other drugs. Dogs with the mutation will react to those drugs.
MDR1 : Multidrug Resistance 1 is inherited as an autosomal incomplete dominant disease. Dogs only need to inherit one copy of the MDR1 mutation to be at risk for sensitivity of certain drugs. Dogs with 2 copies of MDR1 can have more severe reactions.
Please speak with your veterinarian about testing for MDR1 if you own a breed of dog which may have MDR1 gene.
Give this medication with or without food. The medication is meant to be chewed before swallowing. It may be necessary to break the chewable into smaller pieces and hand feed as treats. Ensure that your pet consumes the entire dose.
Give medication as directed by your veterinarian. This medication is often given seasonally.
As a heartworm preventative, this medication is given once a month, beginning within a month after the pet's first exposure to mosquitoes. The medication kills the parasites acquired during the previous month. The final dose should be given within a month of the last exposure to mosquitoes.
Monthly treatment also provides effective treatment and control of roundworms and hookworms.
Ideally, give the medication on or about the same day each month.
If a dose is missed, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time. If you miss more than 8 weeks in a row, give the drug as soon as you remember, but you should have your pet's blood tested for heartworms within 6 months (as infection may have occurred).
Talk to your veterinarian about:
- When will your pet need to be rechecked
- Whether a blood test will need to be performed prior to treatment with this drug
- Risks and benefits of using this drug
Tell your veterinarian about:
- If your pet has experienced side-effects on other drugs/products
- If your pet has experienced digestive upset now or ever
- If your pet has experienced liver or kidney disease now or ever
- If your pet has experienced any other medical problems or allergies now or ever
- All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
Store in a tight, light resistant, childproof container in a cool, dry place at room temperature away from heat and direct sunlight.
People should not take this product. Keep this and all medication out of reach of children and pets. Call your physician immediately if you accidentally take this product.
- When the parasites begin to die off, the animal may experience a mild hypersensitivity reaction including diarrhea
- Self-limiting reactions may include lethargy, vomiting, diarrhea, decreased appetite, staggering, hypersalivation, convulsions within 24 hours of treatment
- It is important to stop therapy and contact your veterinarian immediately if you think your pet has a medical problem or side effect from this product's therapy
- Yes, when ivermectin and pyrantel are used at the recommended dose, there are no contraindicated drugs. When higher doses are used, interactions may occur with amitraz dips and collars (Mitaban®, Preventic®), spinosad (Comfortis™) or diazepam or related tranquilizers.
- If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian
Contact your veterinarian immediately if pet consumes more than the prescribed amount.
Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.
As with all prescribed medicines, this product should only be given to the dog/cat for which it was prescribed. It should be given only for the condition for which it was prescribed.
This is just a summary of information about ivermectin and pyrantel pamoate. If you have any questions or concerns about this product or for the condition it was prescribed, contact your veterinarian.