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Spironolactone by Actavis

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General Description:

Spironolactone is a diuretic used in dogs and cats to remove excess fluid from the body. This drug has been chosen because your pet has not responded to other types of diuretics. Unlike other diuretics, spironolactone does not cause blood potassium to be lost.

What is this drug?
  • Spironolactone is a diuretic (helps the body lose water via increased urine production)
  • Spironolactone is given by mouth
Reasons for prescribing:
  • Because this drug helps remove excessive fluids from the body, it is useful in the treatment of congestive heart failure, ascites and edema
What dogs/cats should not take this medication?
  • Pets with high blood potassium levels, or those with, or at risk for, Addison's disease (hypoadrenocorticism) or diabetes
  • Use with caution in pets with kidney or liver disease
  • Pets taking the drug mitotane (treatment for Cushing's disease)
  • Pregnant and nursing pets
  • Pets known to have had an allergic reaction to spironolactone

Give this medication with food to increase its absorption and lessen stomach upset. Ideally, give the medication at the same time daily.

Give medication as directed by your veterinarian. This medication is usually given once or twice daily . Give the exact amount prescribed and only as often as directed. Missed doses reduce the effectiveness of therapy. Do not suddenly stop this medication.

This product may be provided to you as tablets. If it is difficult for you to administer tablets to your pet, your veterinarian may be able to have it formulated as an oral liquid or a transdermal gel.

Ensure your pet has plenty of food and fresh, clean drinking water while taking spironolactone. It is important that your pet eats and drinks well to decrease the likelihood of side effects. Speak to your veterinarian if your pet does not eat or drink well.

Your pet will have to urinate more frequently than normal and 'accidents' are possible.

What if dose is missed?

If a dose is missed, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.

What to tell/ask veterinarian before giving medication?

Talk to your veterinarian about:

  • When will your pet need to be rechecked
  • What tests may need to be performed prior to and during treatment with this drug
  • Risks and benefits of using this drug

Tell your veterinarian about:

  • If your pet has experienced side-effects on other drugs/products
  • If your pet has experienced digestive upset now or ever
  • If your pet has experienced liver or kidney disease now or ever
  • If your pet has experienced any other medical problems or allergies now or ever
  • All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
  • If your pet is pregnant or nursing or if you plan to breed your pet
Storage and Warnings:

Store in a tight, light resistant, childproof container in a cool, dry place at room temperature away from heat and direct sunlight.

Store oral liquids in the refrigerator. Follow expiry date notification. Shake well before use.

Keep this and all medication out of reach of children and pets. Call your physician immediately if you accidentally take this product.

Potential side effects:
  • Dehydration with excessive thirst and increased urine production is the ddesired effect.
  • Electrolyte (salts) imbalances may occur. Weakness or lethargy could indicate potassium levels have become too high. Weakness and confusion could indicate low sodium levels. Vomiting and diarrhea occurs in some animals. Contact your veterinarian if your pet shows these effects.
  • If you notice anything unusual, contact your veterinarian
Can this drug be given with other drugs?
  • Yes, but possible interactions may occur with ACE inhibitors (enalapril, captopril or lisinopril), ammonium chloride, aspirin, digoxin, epinephrine, indomethacin, glipizide, mitotane, NSAIDs, other diuretics or heart or blood pressure medications, potassium supplements, protein-binding drugs
  • If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian

Contact your veterinarian immediately if pet consumes more than the prescribed amount.

What else should I know?

Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.

As with all prescribed medicines, spironolactone should only be given to the dog/cat for which it was prescribed. It should be given only for the condition for which it was prescribed. It is important to periodically discuss your pet's response to spironolactone at regular check ups. Your veterinarian will best determine if your pet is responding as expected and if your pet should continue receiving spironolactone.

This is just a summary of information about spironolactone. If you have any questions or concerns about spironolactone or for the condition it was prescribed, contact your veterinarian.


Generic Name
Spironolactone Spironol
Generic products are available.

Common Brand Names

Store at room temperature in a tight, light resistant, childproof container.

Spironolactone is a diuretic used to remove excess fluid from the body. Used to treat congestive heart failure and ascites (fluid in the abdomen). It is often used when the pet does not respond to other diuretics. It does not cause the loss of potassium in the blood like other diuretics (Furosemide, Lasix).

Dose and Administration
Always follow the dosage instructions provided by your veterinarian.
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give 2 doses at once.
If you have difficulty giving the medication, contact your veterinarian.
This medication should only be given to the pet for whom it was prescribed.
Food may increase the absorption of spironolactone. Consult your veterinarian about giving this medication with food.
If using the transdermal gel, apply to the skin as directed by your veterinarian.

Possible Side Effects
May cause dehydration with excessive thirst and decreased urine production; or electrolyte imbalances (e.g., high potassium and low sodium), often with weakness, stumbling, or lack of energy. May cause vomiting and diarrhea in some animals. If you see any of these signs, contact your veterinarian immediately.
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Not for use in animals hypersensitive (allergic) to spironolactone.
Do not use in pregnant or lactating animals (female animals nursing their young).
Do not use in animals with high potassium levels in the blood, or Addison?s disease (hypoadrenocorticism).
Use with extreme caution in animals with liver or kidney disease.
Do not use in animals with Cushing?s disease (hyperadrenocorticism) who are taking the medication mitotane.
Spironolactone will cause your pet to urinate more often. Your pet may have more ?accidents? and need to go outside or use the litter box more.
Your pet needs to eat and drink well while taking spironolactone or the risk of side ef­fects increases. Contact your veterinarian if your pet is not eating or drinking well.
Consult with your veterinarian regarding the physical examinations and laboratory testing necessary prior to and during treatment with spironolactone.

Drug and Food Interactions
Notify your veterinarian of any other medications, including vitamins and supplements, your pet is taking while your pet is receiving spironolactone.
Do not give with potassium supplements.
If used with ACE inhibitors (heart medications such as enalapril or captopril), may increase the risk of high blood potassium levels.
May alter the level of the medication, digoxin, in the blood, and require extra monitoring of the blood levels of digoxin.
Aspirin may decrease the effects of spironolactone.

Signs of Toxicity/Overdose
May see weakness, stumbling, lack of energy, vomiting, diarrhea, increased thirst, and increased urination. If you observe any of these signs in your pet, contact your veterinarian immediately.
Keep this and all other medications out of the reach of children and pets.

This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times.  Always consult your own veterinarian for specific advice concerning the treatment of your pet.



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