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Advantage II for Dogs

Advantage II for Dogs by Bayer Animal Health Direct

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Advantage® II Canine

Advantage II for Dogs Generic Name:

Imidacloprid + Pyriproxyfen for Dogs

Advantage II General Description:

Imidacloprid + Pyriproxyfen for Dogs is a topical insecticidal agent used in dogs once a month for the prevention and treatment of flea and lice infestations on dogs. Kills existing fleas within 12 hours. Imidacloprid + Pyriproxyfen for Dogs is applied to the skin on the dog’s back every 30 days. Dogs should be greater than 7 weeks of age. Imidacloprid + Pyriproxyfen for Dogs is available in 4 sizes (based upon body weight).

What is Advantage II for Dogs?
  • Imidacloprid + Pyriproxyfen for Dogs is an insecticidal agent
  • Imidacloprid + Pyriproxyfen for Dogs is applied topically once a month
Reasons for prescribing flea and tick medication:
  • Kills all life stages of fleas for up to four weeks
  • Treats, prevents and controls lice infestations
  • Waterproof and fragrance-free
What pets should not take Advantage II for Dogs?
  • Puppies less than 7 weeks of age
  • Consult your veterinarian before using on older, debilitated, pregnant or nursing dogs
  • Pets known to have had an allergic reaction to imidacloprid, pyriproxyfen or like products

Be sure to follow the dosage instructions provided by your veterinarian. If you have difficulty applying the medication, contact your veterinarian.  Holding applicator tube in upright position, pull cap off tube. Turn the cap around and place the end of cap back on the tube. Twist the cap to break the seal, then remove cap from tube.  For easier application, ensure that your dog is standing. Using the applicator tip, part the hair to expose the skin.  Apply imidacloprid carefully to the skin between your pet's shoulder blades. For medium and larger dogs, squeeze contents evenly to three or four spots along the top of the back from the shoulder to the base of the tail.  To prevent run-off, do not apply an excessive amount at any one spot.  Use the entire contents of the tube that correctly corresponds with the body weight of your dog. Use only one tube per treatment.  Do not allow pets to lick the product or ingest in any way. If you have multiple pets, keep them separated for a short time to prevent licking.  Repeat application monthly. Mark your calendar with the dates of subsequent treatments.  After applying this product to your pet, wash your hands with soap and water. Small children should avoid handling the treated dog for a day or two.  For external use only. Do NOT give by mouth. Keep the product away from your dog's eyes and mouth.  Under normal conditions the product is effective for a month. However, in case of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every 7 days. Once flea control is obtained, return to a monthly retreatment schedule.  Pre-existing pupae in the environment may continue to emerge for 6 weeks or longer depending upon the climatic conditions.  Fleas, flea eggs, and flea larvae in the dog’s environment are killed following contact with an Imidacloprid + Pyriproxyfen-treated pet.  Waterproof and remains effective following a shampoo treatment, swimming or after exposure to rain or sunlight.  Monthly treatments are required for optimal control and prevention of fleas.  Read and follow the label carefully.

What if dose is missed?

If a dose is missed, apply it as soon as you can and resume the monthly dosing schedule. Do not give two doses at the same time.

What to tell/ask veterinarian before giving Advantage II for Dogs?
Talk to your veterinarian about:
  • What tests may need to be performed prior to and during treatment with this drug
  • What are the risks and benefits are of using this drug
Tell your veterinarian about:
  • If your pet has experienced side-effects on other drugs/products
  • If your pet has experienced any other medical problems or allergies now or ever
  • All medicines and supplements including flea and tick products that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together
  • If your pet is pregnant, nursing or if you plan to breed your pet
Storage and Warnings:
  • For external use on dogs only. Do not get this product in dog's eyes or mouth.
  • Store in a cool, dry place. Protect from freezing.
  • Causes eye irritation. Harmful if swallowed. Do not get in the eyes or on clothing. Avoid contact with skin. Wash hands thoroughly with soap and water after handling.
  • People should not use this product. Keep this and all medication out of reach of children and pets. Call your physician immediately if you accidentally take this product.
  • Do not contaminate water or food by storage or disposal. Do not re-use empty container. Securely wrap original container in several layers of newspaper and discard in trash.
Potential side effects of Advantage II for Dogs:
  • Individual sensitivities may occur with any pesticide product. If they occur, consult your veterinarian immediately. If signs persist, or become more severe, consult a veterinarian immediately.
Can this drug be given with other drugs?
  • Yes, but ensure that your veterinarian knows of all of the medicines and supplements that you are giving or planning on giving to your pet.
  • If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian.

In case of overdose, contact your veterinarian immediately or call 1-800-422-9874.

What else should I know about Advantage II for Dogs?

Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.

As with all prescribed medicines, Imidacloprid + Pyriproxyfen for Dogs should only be applied to the dog for which it was prescribed.

This is just a summary of information about Imidacloprid + Pyriproxyfen for Dogs. If you have any questions or concerns about Imidacloprid + Pyriproxyfen for Dogs, or for the condition(s) it was prescribed, contact your veterinarian.


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