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Sentinel Spectrum

Sentinel Spectrum by Novartis

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One monthly Sentinel Spectrum tablet gives your dog protection from heartworm, fleas, hookworms and more. Dogs love the beef flavored tablets!

  • Prevents heartworm and hookworm in dogs
  • Controls fleas and breaks the flea lifecycle
  • Kills and controls roundworms, tapeworm and whipworms
  • Easy dosing flavored tablets

To give your dog broad-spectrum protection from dangerous pests talk to your veterinarian about prescription Sentinel Spectrum. Each chewable tablet contains a combination of milbemycin oxime and lufenuron that work together to protect your dog from pests and parasites for a full month. The active ingredients stop heartworm larvae from developing while killing adult hookworms, whipworms, tapeworm and roundworms. They also stop flea eggs from hatching so the flea life cycle is broken and your pet is protected from reinfestation. The tablets are beef flavored for no hassle dosing.

Milbemycin oxime + Lufenuron + Praziquantel
(Sentinel Spectrum)

Common Drug Name

Milbemycin oxime + Lufenuron+ Praziquantel

Common Brand Names 
Sentinel Spectrum 
No generic products are available. 

Store at room temperature. 


Milbemycin oxime is used as a heartworm preventive, and treats and controls roundworms, hookworms, and whipworms. Lufenuron is used for the prevention and control of flea populations by stopping flea egg development. Praziquantel is used for the treatment and control of tapeworms. 

Dose and Administration 
Do not use in puppies less than 6 weeks of age or less than 2 pounds. Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian. 

This  medication  should always be given immediately after or with a meal to ensure adequate absorption. The chewables can be given by hand or added  to a small amount of dog food but they should be chewed rather than swallowed whole. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole. Be sure the entire dose has been consumed. If it is not entirely consumed, redose once with the full recommended dose as soon as possible. If a dose is missed, give the tablet immediately and resume giving a tablet every 30 days, preferably on the same day each month. 
This medication should only be given to the pet for whom it was prescribed.

Possible Side Effects 
Side effects are uncommon at the recommended heartworm prevention dosage. May see vomiting, depression/lethargy, staggering, loss of appetite, diarrhea, seizures, weakness, or excessive salivation. If you observe any of these signs, contact your veterinarian.

If your pet experiences an allergic reaction to the medication or to dying heartworm larvae (microfilariae), signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Not for use in animals who are hypersensitive (allergic) to any of the ingredients. 
Consult your veterinarian regarding heartworm testing for your pet prior to, and during, treatment with this medication. If you have switched heartworm products, contact your veterinarian regarding the recommendation  to have your pet heartworm  tested  in 6-7 months. 

Treatment with fewer than 6 monthly doses after the last exposure to mosquitoes may not provide complete heartworm  protection. 

Not for use in Collies or other herding breeds over the recommended heartworm prevention dose unless under the strict supervision of a veterinarian. 

The safety of this medication has not been evaluated in dogs used for breeding or in lactating females. Studies have been performed with milbemycin oxime and lufenuron alone (see product insert). 

Properly dispose of unused milbemycin, as it may be toxic to fish and other animals. 

Human Precautions
Some intestinal parasites may be zoonotic (able to infect humans). Consult your veterinarian or physician on how to prevent human infection and reinfection of your pet. 

Drug, Food and Test Interactions
Notify your veterinarian of any other medications, including vitamins and supplements, your pet is taking while your pet is receiving this product. 
No known drug or food interactions.

Signs of Toxicity/Overdose
Uncommon when given at the recommended dose. May see any of the above side effects. 
If you know or suspect your pet has had an overdose, or if you observe any unusual signs, symptoms, or behaviors, contact your veterinarian immediately.

Keep this and all other medications out of the reach of children and pets.

Customer Reviews

Average Customer Rating: (Excellent) based on 1 review
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277 of 592 found the following review helpful:
sentinel spectrum
5 Stars
by a member from cinrti ohii on Dec 15, 2015

Great product

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