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Temaril-P by Zoetis

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What is Temaril-P?
Temaril-P is used to treat itching and coughing (including kennel cough) in dogs. Temaril-P requires a prescription from your veterinarian, and is sold per tablet.

For: Dogs


  • Easy to administer
  • Comes in scored tablet to break in half for smaller dogs

How it works:
Temaril-P contains trimeprazine and prednisolone. Trimeprazine is an antihistamine, which helps relieve itching and coughing. Prednisolone is a corticosteroid that reduces inflammation.

Temaril-P should be given with food to prevent stomach upset. May cause drowsiness. Do not give to pregnant dogs.

More Information:

Brand Name
Temaril-P (Pfizer Animal Health)

Generic Name
Trimeprazine with prednisolone (tri-mep’-rah-zeen)

What is the most important information I should know about Temaril-P:
Temaril-P is a prescription medication that is FDA approved for use in dogs. Temaril-P is available as a scored tablet containing trimeprazine tartrate equivalent to 5mg trimeprazine and prednisolone 2mg. Prolonged use of Temaril-P should not be stopped suddenly. There should be a gradual reduction in dosage before stopping. Temaril-P should be taken with food to lessen stomach upset.

What is Temaril-P:
Temaril-P is a combination antihistamine (trimeprazine) and corticosteroid (prednisone). Temaril-P is used for the relief of itching regardless of cause. It is also used in the treatment of various cough conditions such as kennel cough, bronchitis and coughs of nonspecific origin. Temaril-P may also be used for purposes other than those listed in this guide.

What should I discuss with my veterinarian before giving Temaril-P to my pet:
Do not give Temaril-P to your pet if the pet has a serious viral or fungal infection. Temaril-P can be given in the presence of acute or chronic bacterial infections provided the infection is controlled by antibiotic. Temaril-P may weaken the pet's immune response and its ability to fight infections. Tell your veterinarian if your pet has diabetes mellitus or any other medical conditions. Tell your veterinarian if your pet is being giv en phenytoin, Phenobarbital, diuretics, or insulin. Also tell your veterinarian if the pet is pregnant or lactating.

How should this medication be given:
Give this medication exactly as directed by your veterinarian. Do not give more or less than is prescribed by the veterinarian. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. The usual dose of Temaril-P is based on weight. For dogs up to 10 lbs gibe 1/2 tablet, for 11-20 lbs give 1 tablet, 21-40 lbs give 2 tablets and 41 lbs and up give 3 tablets. These tablets are given twice a day. After 4 days, the dose is typically reduced to 1/2 the initial dose. Keep plenty of water available for the pet. Temaril-P should be given with food. Store Temaril-P at room temperature away from moisture and heat. Keep this medication away from children and pets.

What happens if I miss giving a dose:
Give the missed dose as soon as you remember. However, if is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not give a double dose of the medication.

What happens if I overdose the pet:
Seek emergency veterinary medical treatment. Symptoms of overdose may include excess drowsiness, low blood pressure, and seizures.

What should I avoid while giving Temaril-P to my pet:
Do not give Temaril-P to dogs allergic to it or to either of its ingredients. Temaril-P should not be given to dogs that are pregnant or that are diabetic. Temaril-P may cause drowsiness. Do not use any vaccines without checking with the veterinarian.

What are the possible side effects of Temaril-P:
If any of the following serious side effects occur, stop giving Temaril-P and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives). Trimeprazine can cause drowsiness, tremors and muscle weakness. Prednisolone may cause symptoms of Cushing¿s disease which include increased thirst, urination and hunger as well as vomiting and diarrhea. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.

What other drugs will affect Temaril-P:
Do not give any other over the counter or prescription medications, including herbal products, during treatment with Temaril-P without first talking to the veterinarian. Many other medications can interact with Temaril-P resulting in side effects or altered effectiveness. These include sedatives, anesthetics, pain medications, epinephrine and procaine.


Trimeprazine & Prednisolone

Common Drug Name
Trimeprazine with prednisolone

Common Brand Names
No generic products are available.
Compounded products may be available.

Store in a tight, light resistant, childproof container at room temperature.

Trimeprazine is an antihistamine that relieves itching and cough. Prednisolone is a corticosteroid that reduces inflammation. The combination is used to treat coughing from allergic bronchitis, infections, and non-specific causes.  It is also used to treat itching and inflammation of the skin due to allergies, eczema, or certain infections.

Dose and Administration
Always follow the dosage instructions provided by your veterinarian.
Give with food to decrease chance of stomach ulcers and bleeding.
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give two doses at once.
This medication should only be given to the pet for whom it was prescribed.

Possible Side Effects
Side effects may include sedation, exposed third eyelid, muscle tremors, weakness, blood disorders, and an increase in drinking, eating, and urinating. Your pet may have more “accidents” and need to go outside or use the litter box more often. Less common side effects include increased appetite, weight gain, panting, diarrhea, vomiting, and behavior changes.  Side effects of long-term use include muscle loss, weakness, and the develop­ment of diabetes or hyperadrenocorticism (Cushing's disease). The typical signs of these diseases are increased thirst, urination, and appetite. Animals with Cushing's disease may also develop thin skin, a poor hair coat, and a “pot-belly.”
Immune system suppression may occur, especially on higher doses, making a pet more susceptible to infection. Contact your veterinarian if your pet has a fever (over 103° F), painful urination (a sign of urinary tract infection), tiredness, sneezing, coughing, or runny eyes.
If your pet has an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Not for use in animals hypersensitive (allergic) to the ingredients.
Bacterial infections need to be controlled with antibiotics before/while using trimeprazine with prednisolone.
Not for use in animals with systemic fungal infections, some types of mange (mites), stomach ulcers, Cushing's disease, high blood pressure, kidney disease, or congestive heart failure.
Do not use in pregnant animals. May cause premature birth. Can cause birth defects in dogs, rabbits, and rodents.
If on long-term therapy, do not discontinue the drug abruptly, since it may cause signs of Addison's disease, such as vomiting, weakness, collapse, and sudden death. Taper off the dose over several days. 
Consult with your veterinarian regarding the physical examinations and laboratory testing necessary prior to and during treatment with trimeprazine/ prednisolone.

Drug, Food, and Test Interactions
Notify your veterinarian of any other medications, including vitamins and supplements, your pet is taking while your pet is receiving this medication.
Consult your veterinarian before using trimeprazine/prednisolone with organophosphates, procaine hydrochloride phenytoin, digitalis, epinephrine, phenobarbital, amphotericin B, rifampin cyclosporine, estrogens, erythromycin, mitotane, quinidine, sedatives, general anesthetics, pain medications, Pepto-Bismol, other antidiarrheal mixtures, or antacids, since interactions may occur.
Increased risk of ulcers if used with non­steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, carprofen (Rimadyl), deracoxib (Deramaxx), or etodolac (EtoGesic).
Insulin requirements may increase in diabetic animals.
Do not use modified live vaccines in ani­mals on higher doses of corticosteroids.
Corticosteroids may cause abnormal levels of hepatic enzymes, thyroid hormone, cholesterol, and potassium in the blood, and can affect many laboratory tests. Make sure your veterinarian knows your pet is taking corticosteroids prior to testing.

Signs of Toxicity/Overdose
May see excessive sedation, low blood pressure, slowed breathing and heart rates, pale gums, unsteady movements, seizures, or unconsciousness If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately. 
A chronic overdose is likely to cause signs of Cushing's disease or diabetes mellitus. 
Keep this and all other medications out of the reach of children and pets.

This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times. Always consult your own veterinarian for specific advice concerning the treatment of your pet.


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