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Desmopressin

Desmopressin by Watson Labs

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DDAVP® Tablets (desmopressin acetate) are a synthetic analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation.

DDAVP Tablets contain either 0.1 or 0.2 mg desmopressin acetate. Inactive ingredients include: lactose, potato starch, magnesium stearate and povidone.

INDICATIONS

Central Diabetes Insipidus: DDAVP Tablets are indicated as antidiuretic replacement therapy in the management of central diabetes insipidus and for the management of the temporary polyuria and polydipsia following head trauma or surgery in the pituitary region. DDAVP is ineffective for the treatment of nephrogenic diabetes insipidus.

Patients were selected for therapy based on the diagnosis by means of the water deprivation test, the hypertonic saline infusion test, and/or response to antidiuretic hormone. Continued response to DDAVP can be monitored by measuring urine volume and osmolality.

Primary Nocturnal Enuresis: DDAVP Tablets are indicated for the management of primary nocturnal enuresis. DDAVP may be used alone or as an adjunct to behavioral conditioning or other non-pharmacologic intervention.

SIDE EFFECTS

Infrequently, large doses of the intranasal formulations of DDAVP and DDAVP Injection have produced transient headache, nausea, flushing and mild abdominal cramps. These symptoms have disappeared with reduction in dosage.

Central Diabetes Insipidus: In long-term clinical studies in which patients with diabetes insipidus were followed for periods up to 44 months of DDAVP Tablet therapy, transient increases in AST (SGOT) no higher than 1.5 times the upper limit of normal were occasionally observed. Elevated AST (SGOT) returned to the normal range despite continued use of DDAVP Tablets.

Primary Nocturnal Enuresis: The only adverse event occurring in ≥ 3% of patients in controlled clinical trials with DDAVP Tablets that was probably, possibly, or remotely related to study drug was headache (4% DDAVP, 3% placebo).

Other: The following adverse events have been reported however their relationship to DDAVP has not been established: abnormal thinking, diarrhea, and edema-weight gain.

See WARNINGS for the possibility of water intoxication and hyponatremia.
 

DDAVP® Tablets 

Common Drug Name
Desmopressin Acetate

Storage
Different strengths or dosage forms of desmopressin acetate may have different storage requirements. Read the labeling or ask your pharmacist for the storage requirements of the prescription you receive. 

Uses
Desmopressin Acetate is a synthetic form of the hormone vasopressin. Vasopressin, which is also called anti-diuretic hormone, is responsible for regulating how much water the body retains and how much urine the kidneys produce. Animals that do not make enough vasopressin have a medical condition known as Central Diabetes Insipidus. Desmopressin acetate is the treatment of choice for central diabetes insipidus in both dogs and cats. Because there are a number of different causes of increased water consumption and increased urine production, desmopressin acetate can also be used to help make a diagnosis.

A less common use for desmopressin acetate is in animals with an inherited bleeding disorder called type 1 Von Willebrand’s disease. In this instance it may be used by a veterinarian at the time of surgery.  

Like many other drugs in veterinary medicine, this drug is not FDA approved for use in animals and is not available from a veterinary pharmaceutical manufacturer. Instead, it is compounded by a specialty pharmacy. 

Dose and Administration
Give this medication to your pet exactly as your veterinarian prescribes. If you miss giving your pet a dose of desmopressin acetate, give the next dose as soon as you remember or, if it is close to the next scheduled dose, return to the regular schedule. Do not double dose to catch up. 
Desmopressin acetate is usually given as an eye drop. Your veterinarian may give it by intravenous injection or by injection under the skin. It can not be given by mouth.
When desmopressin acetate is used to treat central diabetes insipidus, it is generally given once or twice a day in the conjunctiva (lower eyelid sac).
Wash your hands after giving your pet this medication.Be sure to discuss any side effects with your veterinarian immediately.

Possible Side Effects
Desmopressin acetate can cause irritation to the eye or conjunctiva.
Too much desmopressin acetate will cause swelling and water retention. At the beginning of treatment you may need to work with your veterinarian to arrive at the appropriate dose for your pet.

Precautions
Keep this and all drugs out of reach of children. Desmopressin acetate is a prescription drug and should be used according to your veterinarian’s directions. It should only be given to the animal for which it was prescribed. Do not give this medication to a person.

Desmopressin acetate should not be used in animals that are prone to forming blood clots. This includes most animals with underlying heart disease.

Desmopressin acetate has not been studied in pregnant dogs or cats. Large doses have been given to pregnant laboratory animals without apparent harm to the fetus. It should only be used if the benefits outweigh the potential risk.

Drug, Food and Test Interactions
Be sure to review with your veterinarian any medications or supplements your pet may be receiving.
The following drugs may increase the effects of desmopressin acetate: fludrocortisone, chlorproamide and urea.

Signs of Toxicity/Overdose
If you suspect your pet or another animal was overdosed accidentally or has eaten this medication inadvertently, contact your veterinarian or the A.S.P.C.A.’s Animal Poison Control Center at 888.426.4435. Always bring the prescription container with you when you take your pet for treatment.

 

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