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Doxycycline by Par Pharm

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General Description:

Doxycycline is an oral tetracycline antibiotic used in dogs and cats to treat many bacterial infections, especially those carried by ticks. To reduce stomach upset, give doxycycline with a meal. Doxycycline is available as tablets, capsules, oral suspension or as an injection. A gel formula is also used after some dental procedures.

What is this drug?
• A tetracycline antibiotic
• Given by mouth or as a dental preparation

Reasons for prescribing:
• Useful to treat a variety of bacterial infections in dogs and cats including leptospirosis, toxoplasmosis and many diseases carried by ticks
• Gel formulation is used in dogs after dental surgery to fight bacteria causing periodontal disease

What dogs/cats should not take this medication?
• Pets known to have had an allergic reaction to doxycycline or other antibiotics
• Use with caution in pregnant females
• Nursing females and young animals


For liquids, shake well before accurately measuring the dose.

Give with food to reduce the incidence of vomiting.

When pilling cats, ensure that the medication is followed by at least a teaspoon of water or a favorite liquid (tuna water). Do not 'dry-pill'.

Give doxycycline 1-2 hours before or after any supplements or medications containing aluminum, calcium, magnesium or zinc.

Give doxycycline 3 hours before or 2 hours after any oral iron supplements or medications.

Give medication as directed by your veterinarian. This medication is usually given once or twice daily .

Read and follow the label carefully.

Give the exact amount prescribed and only as often as directed. Missed doses reduce the effectiveness of therapy.

Finish the entire course of treatment.

Ideally, give the medication at the same time daily.

What if dose is missed?

If a dose is missed, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.

What to tell/ask veterinarian before giving medication?

Talk to your veterinarian about:
• When will your pet need to be rechecked
• What tests may need to be performed prior to and during treatment with this drug
• Risks and benefits of using this drug

Tell your veterinarian about:
• If your pet has experienced side-effects on other drugs/products
• If your pet has experienced digestive upset now or ever
• If your pet has experienced liver disease now or ever
• If your pet has experienced any other medical problems or allergies now or ever
• All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
• If your pet is pregnant or nursing or if you plan to breed your pet

Storage and Warnings:

Store capsules and tablets in tight, light resistant, childproof containers in a dry place at room temperature away from heat and direct sunlight.

After reconstitution, the oral suspension is stable for 14 days at room temperature. Do not refrigerate.

Keep this and all medication out of reach of children and pets. Call your physician immediately if you accidentally take this product.

Pet owners allergic to doxycycline and/or other tetracycline antibiotics should use caution when handling this drug.

Potential side effects:
• Decrease in appetite, nausea, vomiting and diarrhea. Contact your veterinarian if pet experiences severe vomiting or diarrhea.
• Bone and teeth abnormalities in young animals are less likely with doxycycline than other tetracyclines
• Damage to esophagus in cats from 'dry-pilling'. Ensure cat eats or drinks after receiving capsule or tablet form
• Superinfections have occurred in long-term tetracycline therapy
• Skin sensitivities (pustules or blisters on skin exposed to sun). Use caution when exposing pet to sunlight.
• Reported cases in human medicine of liver conditions and blood abnormalities
• It is important to stop therapy and contact your veterinarian immediately if you think you pet has a medical problem or side effect from this product's therapy

Can this drug be given with other drugs?
• Yes, but possible interactions may occur with aminogylcosides, barbiturates, bismuth, carbamezine, cephalosporins, kaolin, digoxin, insulin, laxatives, medications/supplements containing aluminum, calcium, iron, magnesium and/or zinc, oral antacids, oral sodium bicarbonate, pectin, penicillins, theophylline, and warfarin.
• If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian


Contact your veterinarian immediately if pet eats more than the prescribed amount.

What else should I know?

Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.

Dogs prescribed Doxirobe Oral Gel should not have teeth brushed for 2 weeks following application.

As with all prescribed medicines, doxycycline should only be given to the dog/cat for which it was prescribed. It should be given only for the condition for which it was prescribed.

This is just a summary of information about doxycycline. If you have any questions or concerns about doxycycline or for the condition it was prescribed, contact your veterinarian.


Common Drug Name

Common Brand Names
Doxirobe (oral gel veterinary form) Vibramycin , Monodex (human form)
Generic products are available.

Unless otherwise stated by the manufac­turer, store in tightly closed container at room temperature (60-86°F), protected from light, heat, and moisture (not in the bathroom). 
Once the oral suspension is reconstituted (the powder is mixed with water), store at room temperature and use within 14 days.

Dogs: Doxycycline is a broad-spectrum antibiotic commonly used for the treat­ment of bacterial infections, leptospirosis, toxoplasmosis, and many diseases carried by ticks including Lyme disease, ehrlichiosis, Rocky Mountain spotted fever, and salmon poisoning. Doxirobe, an oral gel, can be applied to pockets between the gums and teeth to fight bacteria causing dental disease.
Cats: Doxycycline is used for the treat­ment of bacterial infections, haemobartonellosis, ehrlichiosis, and toxoplasmosis.
Rabbits, Chinchillas, Mice, Rats, Gerbils, Hamsters, and Guinea Pigs: Used for the treatment of bacterial and mycoplasma infections.
Birds: Used for the treatment of infections, including psittacosis.
Reptiles: Used for the treatment of bacterial and mycoplasma infections.

Dose and Administration
Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.
Use all of the medication prescribed. If your pet does not receive the entire course of treatment, the infection may recur or worsen.
Oral forms may be given with food to decrease side effects.
CAUTION in CATS: If using a tablet or capsule form, you must also give a teaspoon of water after administering the pill, or the medication may cause damage to the esophagus. Alternatively, offer your cat water flavored with tuna water or other liquid your cat likes. You may also get a liquid form of doxycycline for cats.
If you miss a dose, give it as soon as you remember.  If it is almost time for the next dose, skip the one you missed and go back to the regular schedule.  Do not give two doses at once.
This medication should only be given to the pet for whom it was prescribed.

Possible Side Effects
Possible side effects include nausea and vomiting. Contact your veterinarian if you observe any of these effects in your pet.
May cause photosensitivity, with pustules or blisters on skin exposed to the sun.
Long-term therapy may result in the growth of unwanted bacteria or fungi.
May stain the teeth in immature animals, but other tetracyclines more apt to do this.
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Not for use in animals hypersensitive (allergic) to it or other tetracyclines. 
Do not give during the first half of preg­nancy. Can slow the growth, alter the skeleton, and yellow the teeth of unborn animals. Give only during the second half of pregnancy if benefits outweigh the risks.
Consult with your veterinarian regarding the physical examinations and laboratory testing necessary prior to and during treatment with doxycycline. 

Drug, Food, and Test Interactions
Consult your veterinarian before using doxycycline with vitamins and supplements, oral antacids, minerals (especially iron), Pepto-Bismol, or Kaopectate digoxin, theophylline (bronchial dilator), warfarin and insulin, since interactions may occur.
May cause false urine glucose results.

Signs of Toxicity/Overdose
May see loss of appetite, vomiting, and diarrhea.
If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.
Keep this and all other medications out of the reach of children and pets.

This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times. Always consult your own veterinarian for specific advice concerning the treatment of your pet.


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