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Hydroxyzine Pamoate

Hydroxyzine Pamoate by Watson Labs

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Hydroxyzine Pamoate is an antihistamine used for the treatment of allergies in dogs and cats. Hydroxyzine Pamoate requires a prescription from your veterinarian, and is sold per capsule.

For: Dogs and Cats


  • Effective against hives, itching, and rashes
  • Can be used as a mild sedative or tranquilizer for anxious dogs

How it works:
Hydroxyzine blocks the effects of histamine in the body. Hydroxyzine also depresses activity of the central nervous system and is also used to treat anxiety disorders and tension in stressful situations.

It should not be used in pregnant or nursing animals. Hydroxzyzine may cause drowsiness. Be sure to tell your veterinarian about any health conditions or other drugs your dog or cat may be taking.




What is the most important information I should know about hydroxyzine:
Hydroxyzine pamoate (generic for Vistaril) is not FDA approved for use in veterinary medicine; however, it is a commonly accepted practice for veterinarians to use this medication in dogs and cats. Hydroxyzine pamoate is available as 25mg and 50mg capsules. The usual dose of hydroxyzine in dogs is 1mg per pound every 6 to 8 hours. The usual dose in cats is 5 to 10 mg per cat every 8 to 12 hours. Hydroxyzine may cause drowsiness or dizziness.

What is Hydroxyzine:
Hydroxyzine is an antihistamine. It blocks the effects of histamine in the body making it useful to treat allergic conditions that affect the skin such as hives, itching and rashes. Hydroxyzine depresses activity of the central nervous system and is also used to treat anxiety disorders and tension in stressful situations. Hydroxyzine may be used for other purposes than those listed in this guide.

What should I discuss with my veterinarian before giving hydroxyzine to my pet:
Tell your veterinarian if your pet has heart, liver or kidney disease. Tell your veterinarian if your pet is pregnant or lactating.

How should this medication be given:
Follow the instructions on the prescription label. If you do not understand these directions ask your pharmacist or veterinarian to explain them to you. Store hydroxyzine at room temperature away from moisture and heat.

What happens if I miss giving a dose:
Give the missed dose as soon as you remember. However, if it almost time for the next regularly scheduled dose, skip the missed dose and give the next one as directed. Do not give a double dose of the medication.

What happens if I overdose the pet:
Seek emergency veterinary medical attention if you think you have used too much of this medication. Symptoms of overdose may include extreme drowsiness, nausea, vomiting, seizures, and decreased breathing.

What should I avoid while giving Hydroxyzine:
Hydroxyzine can cause drowsiness and dizziness.

What are the possible side effects of Hydroxyzine:
Seek emergency veterinary medical attention if your pet experiences any signs of an allergic reaction (hives; difficulty breathing; swelling of the face, lips, tongue, or throat). Keep giving Hydroxyzine and talk to your veterinarian if your pet develops any of these less serious side effects; dizziness, drowsiness, or confusion; blurred vision or dry mouth; nausea or vomiting. Talk to your veterinarian about any side effect that seems unusual or that is especially bothersome to your pet.

What other medications will affect Hydroxyzine:
Tell your veterinarian if your pet is using any of the following medications; chlorpheniramine (Chlor-Trimeton), celmastine (Tavist), meperidine (Demerol), Phenobarbital, acepromazine, amitriptyline (Elavil), fluoxetine (Prozac). Tell your veterinarian about all prescription and non-prescription (OTC) medications, including vitamins, minerals, and herbal products.


(Atarax, Vistaril)

Common Drug Name
Generic products are available.

Common Brand Names
Atarax (Hydroxyzine HCl) Vistaril (Hydroxyzine pamoate)

Store at room temperature in a tight, light resistant, childproof container. Avoid freezing liquid products.

Dogs, Cats, and Ferrets: Hydroxyzine is an antihistamine used for the treatment of allergies, flea bite dermatitis, and atopy, primarily to stop itching. (Atopy is an allergy to something that is inhaled, such as pollen or house dust; also called 'inhalant allergy').
Birds: Hydroxyzine is used for the treatment of allergies, feather picking, and self-mutilation.

Dose and Administration
Always follow the dosage instructions provided by your veterinarian.
Duration of treatment depends on the reason for and response to treatment.
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give 2 doses at once.
If you have difficulty giving the medication, contact your veterinarian.
This medication should only be given to the pet for whom it was prescribed.

Possible Side Effects
Dogs: May see sedation. Less commonly seen are excitement, fine tremors, whole body tremors, or seizures.
Cats: May see increased thirst, sedation, or other behavioral changes.
Consult your veterinarian if you notice any of the above side effects.
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Not for use in animals hypersensitive (allergic) to hydroxyzine or similar medications.
Use with caution in animals with hypothyroidism, heart disease, glaucoma, enlarged prostate, severe cardiac failure, or obstruction of the urinary bladder (problems urinating), or obstruction of the pylorus (junction between the stomach and intestine).
Not for use in pregnant and lactating animals (female animals nursing their young).
Do not use in working animals (military dogs, police dogs, seeing eye dogs, hearing dogs, etc.) as it may cause too much sedation.
Discontinue use at least 7 days prior to skin allergy testing.

Drug, Food, and Test Interactions
Consult your veterinarian before using hydroxyzine with any other medications, including vitamins and supplements, other central nervous system (CNS) depressant drugs such as barbiturates, antidepressants, anesthetics, or tranquilizers; anticholinergic drugs, heparin, warfarin, or epinephrine, since interactions may occur.
No known food interactions.

Signs of Toxicity/Overdose
May see excessive sedation or low blood pressure (weakness). If you observe any of these signs in your pet, contact your veterinarian immediately.
Keep this and all other medications out of the reach of children and pets.

This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times.   Always consult your own veterinarian for specific advice concerning the treatment of your pet.


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