Etodolac is an oral nonsteroidal anti-inflammatory drug (NSAID) used in dogs to reduce pain and inflammation due to osteoarthritis. This medication may be given with or without food. Response varies but in most dogs, improvement will be seen in a few days. Etodolac is available as 150 mg and 300 mg tablets.
What is this drug?
Etodolac is a nonsteroidal anti-inflammatory drug (NSAID)
Given to dogs by mouth
Reasons for prescribing?
Used to reduce pain and inflammation (soreness) due to osteoarthritis in dogs [signs include limping or lameness, decreased activity or exercise (reluctance to stand, climb stairs, jump or run, or difficulty in performing these activities), stiffness or decreased movement of joints
What dogs/cats should not take this medication?
Cats (this medication is for dogs only). Call your veterinarian immediately if your cat receives etodolac
Has had an allergic reaction to the active ingredient etodolac
Has had an allergic reaction to aspirin or other NSAIDs (for example, carprofen or phenylbutazone) such as hives, facial swelling, or red or itchy skin
Etodolac should be given according to your veterinarian's instructions. Your veterinarian will tell you what amount of etodolac is right for your dog and for how long it should be given.
Etodolac should be given by mouth and may be given with or without food.
While etodolac is not a cure for osteoarthritis, it can relieve the pain and inflammation of OA and improve your dog's mobility.
Response varies from dog to dog but can be quite dramatic.
In most dogs, improvement can be seen in a matter of days.
If etodolac is discontinued or not given as directed, your dog's pain and inflammation may return.
What to tell/ask veterinarian before giving medication?
Talk to your veterinarian about:
The signs of OA you have observed (for example, limping, stiffness)
The importance of weight control and exercise in the management of OA
What tests might be done before etodolac is prescribed
How often your dog may need to be examined by your veterinarian
The risks and benefits of using etodolac
Tell your veterinarian about:
Experienced side effects from etodolac or other NSAIDs, such as aspirin
Digestive upset (vomiting and/or diarrhea)
Liver and kidney disease
A bleeding disorder (for example, Von Willebrand's disease)
Any other medical problems or allergies that your dog has now or has had
All medicines that you are giving your dog or plan to give your dog, including those you can get without a prescription
If your dog is pregnant, nursing or if you plan to breed your dog
Storage and Warnings:
Store in a tight, light resistant, childproof container at room temperature away from heat and direct sunlight.
For use in dogs only. Do not use in cats.
People should not take etodolac. Keep etodolac and all medicine out of reach of children.
Call your physician immediately if you accidentally take etodolac.
Potential side effects?
Etodolac, like other drugs, may cause some side effects. Serious but rare side effects have been reported in dogs taking NSAIDs, including etodolac. Serious side effects can occur with or without warning and in rare situations result in death.
The most common NSAID-related side effects generally involve the stomach (such as bleeding ulcers), and liver or kidney problems. Look for the following side effects that can indicate your dog may be having a problem with etodolac or may have another medical problem:
Decrease or increase in appetite
Change in bowel movements (such as diarrhea, or black, tarry or bloody stools)
Change in behavior (such as decreased or increased activity level, incoordination, seizure or aggression)
Yellowing of gums, skin, or whites of the eyes (jaundice)
Change in drinking habits (frequency, amount consumed)
Change in urination habits (frequency, color, or smell)
Change in skin (redness, scabs, or scratching)
It is important to stop therapy and contact your veterinarian immediately if you think your dog has a medical problem or side effect from etodolac therapy. If you have additional questions about possible side effects, talk to your veterinarian.
Can this drug be given with other drugs?
Etodolac should not be given with other NSAIDs (for example, aspirin, carprofen) or steroids (for example, cortisone, prednisone, dexamethasone, triamcinolone).
Contact your veterinarian immediately if your dog eats more than the prescribed amount of etodolac.
What else should I know?
This sheet provides a summary of information about etodolac. If you have any questions or concerns about etodolac or osteoarthritis pain, talk to your veterinarian.
As with all prescribed medicines, etodolac should only be given to the dog for which it was prescribed. It should be given to your dog only for the condition for which it was prescribed. It is important to periodically discuss your dog's response to etodolac at regular check ups.
Your veterinarian will best determine if your dog is responding as expected and if your dog should continue receiving etodolac.
Common Drug Name
Common Brand Names
EtoGesic, Lodine (human form)
Generic products are available.
Store at room temperature in a tight, light resistant, childproof container.
Etodolac is a non-steroidal antiinflammatory drug (NSAID) that is approved for use in dogs for management of pain and inflammation associated with osteoarthritis, including hip dysplasia. May be helpful in treating other types of pain or inflammation. It may also help reduce fevers.
Do NOT use in cats.
Dose and Administration
Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.
Etodolac is given by mouth. The chance of stomach/intestinal side effects may be reduced if given with food.
For long-term treatment, use the lowest dose needed to provide relief. For arthritic conditions, etodolac may need to be given periodically for the animal’s lifetime.
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give 2 doses at once.
This medication should only be given to the pet for whom it was prescribed.
Possible Side Effects
The most common side effect of NSAIDs is stomach upset, but stomach ulcers may develop, and you may see loss of appetite; vomiting; diarrhea; dark, tarry or, bloody stools; or constipation. Side effects involving the kidney include increased thirst and urination, or changes in the urine color or smell. Liver-related side effects include jaundice (yellowing of the gums, skin, or eyes). Other side effects may include pale gums, lethargy, shedding, incoordination, seizures, or behavioral changes. If any of these side effects are observed, stop treatment and contact your veterinarian.
May develop keratoconjunctivitis sicca (KCS, dry eye), which may cause painful, irritated, “red” eyes with a thick, mucous discharge. Stop giving the medication and consult your veterinarian if your pet has eye discharge, redness, squinting, or other signs related to the eye.
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.
Not for use in animals who are hypersensitive (allergic) to etodolac (EtoGesic), carprofen (Novox or Rimadyl), aspirin, deracoxib (Deramaxx), meloxicam (Metacam), tepoxalin (Zubrin), firocoxib (Previcox) or other NSAIDs.
The safety of the drug has not been determined in breeding, pregnant, or lactating animals (female animals nursing their young).
The safety of the drug in dogs less than 12 months of age has not been determined.
Use with extreme caution and continued monitoring in geriatric animals and those who are dehydrated or have pre-existing stomach, intestinal, liver, heart, kidney, blood disorders, or diabetes mellitus.
Do not use in animals with bleeding problems, e.g., von Willebrand's disease or with keratoconjunctivitis sicca (dry eye) since it could worsen these conditions.
Consult with your veterinarian regarding the physical examinations and laboratory testing necessary prior to and during treatment with etodolac.
Drug, Food, and Test Interactions
Consult your veterinarian before using etodolac with any other medications, including vitamins and supplements, other NSAIDs (e.g., aspirin, carprofen (Novox or Rimadyl), deracoxib (Deramaxx), tepoxalin (Zubrin), and meloxicam (Metacam), firocoxib (Previcox)); steroids (e.g., prednisone, prednisolone, dexamethasone, triamcinolone, Medrol); methotrexate, diureteics (e.g.furosemide (Lasix)); phenylpropanolamine, enalapril, or phenobarbital, since interactions may occur.
Signs of Toxicity/Overdose
May see loss of appetite, vomiting, diarrhea, dark or tarry stools, bloody stools, increased thirst, increased urination, pale gums, jaundice (yellowing of gums, skin, or eyes), lethargy, increased respiration (fast or heavy breathing), seizures, incoordination, or behavioral changes.
If you know or suspect your pet has had an overdose, or if you observe any of these signs, contact your veterinarian immediately.
Keep this and all other medications out of the reach of children and pets.
This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times. Always consult your own veterinarian for specific advice concerning the treatment of your pet.