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Sucralfate

Sucralfate by Nostrum Laboratories

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Sucralfate

Trade Names:

Carafate®

General Description:

Sucralfate is an oral anti-ulcer drug used in dogs and cats to coat ulcers in the gastrointestinal tract to protect them from stomach acid and allow them to heal. Sucralfate is helpful in many conditions associated with stomach ulcers (ex. poison ingestion, kidney or liver failure, cancer and megaesophagus). Sucralfate is available as an oral liquid or as tablets.

What is this drug?
  • Sucralfate is an anti-ulcer drug; a sucrose aluminum hydroxide compound
  • Sucralfate is given by mouth
Reasons for prescribing:
  • Used to coat ulcers in the mouth, stomach, upper small intestine and esophagus. It protects the ulcer from stomach acid and helps in the healing process too.
  • May be used in any condition associated with stomach ulcers (ex. poison ingestion, kidney and liver failure, some cancers and megaesophagus)
  • Often prescribed with ulcer-causing medications (ex. aspirin, piroxicam)
What dogs/cats should not take this medication?
  • Contistipated animals or those known to have slow movement of food through the digestive system (ex. those with megacolon)
  • Use cautiously in pregnant and nursing animals
  • Pets known to have had an allergic reaction to sucralfate
Directions:

This medication should be given on an empty stomach (at least 1 hour before a meal, or two hours after).

Shake liquid medication well. Tablets are usually crushed to allow better absorption.

Give medication as directed by your veterinarian. This medication is usually given three or four times daily . This ensures continuous protection for the ulcer(s).

Read and follow the label carefully.

Give the exact amount prescribed and only as often as directed. Missed doses reduce the effectiveness of therapy.

The length of therapy depends greatly upon the disease condition as well as the pet's response to sucralfate.

Call ahead for refills.

Ideally, give the medication at the same time daily.

What if dose is missed?

If a dose is missed, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.

What to tell/ask veterinarian before giving medication?

Talk to your veterinarian about:

  • When will your pet need to be rechecked
  • What tests may need to be performed prior to and during treatment with this drug
  • Risks and benefits of using this drug

Tell your veterinarian about:

  • If your pet has experienced side-effects on other drugs/products
  • If your pet has experienced digestive upset now or ever
  • If your pet has experienced liver or kidney disease now or ever
  • If your pet has experienced any other medical problems or allergies now or ever
  • All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
  • If your pet is pregnant or nursing or if you plan to breed your pet
Storage and Warnings:

Store sucralfate in a tight, light resistant, childproof container in a cool, dry place at room temperature away from heat and direct sunlight.

Shake liquids well before using.

Keep this and all medication out of reach of children and pets. Call your physician immediately if you accidentally take this product.

Potential side effects:
  • Constipation
  • With long term use, one of the ingredients (aluminum) may build up and cause the bones to weaken or have an effect on the brain
  • It is important to stop therapy and contact your veterinarian immediately if you think you pet has a medical problem or side effect from this product's therapy
Can this drug be given with other drugs?
  • Yes, but possible interactions may occur with antacids, cimetidine, digoxin, fluorquinolone antibiotics (enrofloxacin, marbofloxacin,orbifloxacin), phenytoin and tetracycline.
  • The above drugs can still be used, but give the sucralfate dose 2 hours before or after the other drug(s).
  • If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian
Overdosing?

Contact your veterinarian immediately if pet eats more than the prescribed amount.

What else should I know?

Notify your veterinarian if your animal's condition does not improve or worsens (blood in the vomit or stools) despite this treatment.

As with all prescribed medicines, sucralfate should only be given to the dog/cat for which it was prescribed. It should be given only for the condition for which it was prescribed.

This is just a summary of information about sucralfate. If you have any questions or concerns about sucralfate or for the condition it was prescribed, contact your veterinarian.

Spironolactone
(Aldactone)

Generic Name
Spironolactone Spironol
Generic products are available.

Common Brand Names
Aldactone

Storage
Store at room temperature in a tight, light resistant, childproof container.

Uses
Spironolactone is a diuretic used to remove excess fluid from the body. Used to treat congestive heart failure and ascites (fluid in the abdomen). It is often used when the pet does not respond to other diuretics. It does not cause the loss of potassium in the blood like other diuretics (Furosemide, Lasix).

Dose and Administration
Always follow the dosage instructions provided by your veterinarian.
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give 2 doses at once.
If you have difficulty giving the medication, contact your veterinarian.
This medication should only be given to the pet for whom it was prescribed.
Food may increase the absorption of spironolactone. Consult your veterinarian about giving this medication with food.
If using the transdermal gel, apply to the skin as directed by your veterinarian.

Possible Side Effects
May cause dehydration with excessive thirst and decreased urine production; or electrolyte imbalances (e.g., high potassium and low sodium), often with weakness, stumbling, or lack of energy. May cause vomiting and diarrhea in some animals. If you see any of these signs, contact your veterinarian immediately.
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Precautions
Not for use in animals hypersensitive (allergic) to spironolactone.
Do not use in pregnant or lactating animals (female animals nursing their young).
Do not use in animals with high potassium levels in the blood, or Addison?s disease (hypoadrenocorticism).
Use with extreme caution in animals with liver or kidney disease.
Do not use in animals with Cushing?s disease (hyperadrenocorticism) who are taking the medication mitotane.
Spironolactone will cause your pet to urinate more often. Your pet may have more ?accidents? and need to go outside or use the litter box more.
Your pet needs to eat and drink well while taking spironolactone or the risk of side ef­fects increases. Contact your veterinarian if your pet is not eating or drinking well.
Consult with your veterinarian regarding the physical examinations and laboratory testing necessary prior to and during treatment with spironolactone.

Drug and Food Interactions
Notify your veterinarian of any other medications, including vitamins and supplements, your pet is taking while your pet is receiving spironolactone.
Do not give with potassium supplements.
If used with ACE inhibitors (heart medications such as enalapril or captopril), may increase the risk of high blood potassium levels.
May alter the level of the medication, digoxin, in the blood, and require extra monitoring of the blood levels of digoxin.
Aspirin may decrease the effects of spironolactone.

Signs of Toxicity/Overdose
May see weakness, stumbling, lack of energy, vomiting, diarrhea, increased thirst, and increased urination. If you observe any of these signs in your pet, contact your veterinarian immediately.
Keep this and all other medications out of the reach of children and pets.

This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times.  Always consult your own veterinarian for specific advice concerning the treatment of your pet.

 

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