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Profender Cat Wormer

Profender Cat Wormer by Bayer Animal Health Direct

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Profender is the first-ever, topical dewormer used to treat and control intestinal parasites in cats, such as hookworms, tapeworms and roundworms. Not only is Profender easy to use, safe and effective, it also works in a single-dose capacity so there is no need for that pesky second dose! Profender requires a prescription from your veterinarian.
 

For: Cats (8 weeks of age or older)

 
Benefits:
Kills hookworms, tapeworms and roundworms
Fast-acting, powerful topical treatment
One-time application
Safe and effective

How it works:
Profender works by using the time-tested active ingredient praziquantel and a unique compound called emodepside to eradicate intestinal parasites. Once Profender encounters your cat's skin, it rapidly enters the bloodstream and travels to the intestines, controlling and eliminating unwanted parasites.

Cautions:
Not for use on kittens under 8 weeks old or those under 2.2 lbs. and safe use in breeding, pregnant, or lactating pets has not been determined. Use with caution in sick or debilitated cats. Keep out of reach of children, and to prevent accidental ingestion of the product, children should not come in contact with the application site for 24 hours while the product is being absorbed. Pregnant women or women who may become pregnant should avoid direct contact with, or wear disposable gloves when applying this product.

Profender®
(emodepside/praziquantel)
Topical Solution

Common Brand Name:
Profender (Bayer)
Generic Name
emodepside + praziquantel

STORAGE INFORMATION
Store at or below 77ºF (25ºC).
Protect from freezing.

Uses
PROFENDER Topical Solution is indicated for the treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae), roundworm infections caused by Toxocara cati (adults and fourth stage larvae), and tapeworm infections caused by Dipylidium caninum (adults) and Taenia taeniaeformis (adults) in cats.

Dosage and Administration

The recommended minimum dose is 1.36 mg/lb (3 mg/kg) emodepside + 5.45 mg/lb (12 mg/kg) praziquantel as a single topical dose. A single treatment is effective and a second treatment should not be necessary. If re-infection occurs, the product can be re-applied after 30 days.

1. Select the package that correctly corresponds with the body weight of the cat. (See Table below.)

Cat

Weight*

Profender

Topical Solution

Volume

(mL)

Emodepside

(mg)

Praziquantel

(mg)

2.2-5.5 lbs.

Small

0.35

7.5

30.0

>5.5-11 lbs.

Medium

0.70

15.0

60.1

>11-17.6 lbs.

Large

1.12

24.0

96.1

2. Remove one unit dose tube from the package.

3. While holding the tube in an upright position, remove the cap from the tube.

4. Turn the cap over and place the other end of cap onto the tip of the tube.

5. Twist the cap to break the seal and then remove cap from the tube.

Picture for tube opening

6. Part the hair on the back of the cat’s neck at the base of the head, until the skin is visible.

Picture to show where to apply product

7. To ensure the entire contents of the tube are administered, place the tip of the tube on the skin and squeeze the entire contents directly onto the skin. Lift tube away from the skin before releasing pressure on the tube.

Do not apply to broken skin or if hair coat is wet.

Do not get this product in the cat’s mouth or eyes or allow the cat to lick the application site for one hour. Oral exposure can cause salivation and vomiting. Treatment at the base of the head will minimize the opportunity for ingestion while grooming. In households with multiple pets, keep animals separated to prevent licking of the application site.

Stiff hair, a damp appearance of the hair, or a slight powdery residue may be observed at the treatment site. These effects are temporary and do not affect the safety or effectiveness of the product.

Possible Side Effects

Field study: In a controlled, double-masked field safety study, owners administered PROFENDER Topical Solution to 606 cats. Adverse reactions reported by the cat owners included licking/ excessive grooming in 18 cats (3.0%), scratching treatment site in 15 cats (2.5%), salivation in 10 cats (1.7%), lethargy in 10 cats (1.7%), alopecia in 8 cats (1.3%), agitation/nervousness in 7 cats (1.2%), vomiting in 6 cats (1.0%), diarrhea in 3 cats (0.5%), eye irritation in 3 cats (0.5%), respiratory irritation in 1 cat (0.2%) and shaking/tremors in 1 cat (0.2%). All adverse reactions were self-limiting.

Laboratory effectiveness studies: One cat died 10 days after receiving PROFENDER Topical Solution. The necropsy showed chronic active cholangiohepatitis. While the use of the drug did not appear to be the direct cause of death, treatment with the drug cannot be ruled out as a contributing factor . One cat treated with a vehicle placebo (formulation minus the active ingredients) showed salivation, gagging, lethargy and a swollen tongue.

Foreign Market Experience: The following adverse events were reported voluntarily during post-approval use of the product in foreign markets: application site reaction (hair loss, dermatitis, pyoderma, edema, and erythema), salivation, pruritus, lethargy, vomiting, diarrhea, dehydration, ataxia, loss of appetite, facial swelling, rear leg paresis, seizures, hyperesthesia, twitching, and death.

Animal Precautions
Safe use of this product has not been evaluated in cats less than 8 weeks of age or weighing less than 2.2 lbs (1 kg), in cats used for breeding, during pregnancy or in lactating queens. The effectiveness of this product when used before bathing has not been evaluated.

Use with caution in sick or debilitated cats. Oral ingestion or exposure should be avoided. Use with caution in heartworm positive cats. The cats enrolled in the field study were heartworm antigen and antibody negative prior to entering the study. In a laboratory study, cats artificially infected with adult heartworms and treated with PROFENDER Topical Solution had fewer worms recovered than the placebo control group. 

Human Warnings
Not for human use. Keep out of reach of children.

To prevent accidental ingestion of the product, children should not come in contact with the application site for twenty-four (24) hours while the product is being absorbed. Pregnant women, or women who may become pregnant, should avoid direct contact with, or wear disposable gloves when applying, this product. Studies performed in rats and rabbits suggest that emodepside may interfere with fetal development in those species.

PROFENDER Topical Solution may be irritating to skin and eyes. Reactions such as facial, tongue and hand swelling have been reported in humans in rare instances. Avoid contact with the application area while it is wet and wash hands thoroughly with soap and warm water after handling. People with known hypersensitivity to butylhydroxyanisole, emodepside or praziquantel should administer the product with caution. If the product accidentally gets into eyes, flush thoroughly with water. May be harmful if swallowed. In case of accidental ingestion or if skin or eye irritation occurs, call a poison control center or physician for treatment advice.

The Material Safety Data Sheet (MSDS) provides additional occupational safety information. For customer service or to obtain product information, including the MSDS, call 1-800-633-3796. For medical emergencies or to report an adverse reaction, call 1-800-422-9874. 

Drug, Food and Test Interactions
Talk to your veterinarian or pharmacist regarding any other medications, including vitamins and supplements, and other flea and tick products your pet is using.

Signs of Toxicity/Overdose
Seek emergency veterinary medical treatment. Symptoms of overdose may include increased salivation, tremors, or drowsiness.

This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times.  Always consult your own veterinarian for specific advice concerning the treatment of your pet. 

 

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