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Fluoxetine capsules

Fluoxetine capsules by Sandoz

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Fluoxetine hydrochloride

Reconcile has been manufacturer discontinued. We recommend this generic cost saving alternative.

Trade Names:

Prozac®
Reconcile®

General Description:

Fluoxetine is an SSRI antidepressant useful in treating separation anxiety, inappropriate urination and many other behavioral issues in dogs and cats. Best results are achieved with most behavior drugs by simultaneous use of behavior modification training. Fluoxetine is available as tablets, chewable tablets, capsules and as an oral liquid.

What is this drug?
  • Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant
  • Fluoxetine is given by mouth
Reasons for prescribing:
  • To reduce separation anxiety and increase receptivity to training techniques that create positive behavior
  • To treat inappropriate urine marking in dogs and cats
  • To treat aggression, thunderstorm phobias plus various obsessive compulsive behaviors such as chewing, circling and self-mutilation
What dogs/cats should not take this medication?
  • Dogs less than 6 months or weighing less than 8.8 lbs
  • Pets also receiving drugs known as MAO inhibitors
  • Use with caution in diabetics and those with liver or kidney disease
  • Pets with a history of seizures
  • Breeding, pregnant or nursing animals
  • Pets known to have had an allergic reaction to fluoxetine or other SSRIs
  • If your pet is presently taking like products (unless directed by your veterinarian)
Directions:

Fluoxetine will be administered in conjunction with a positive behavior modification program. It is essential to follow the training plan as well as administer the medication, to achieve therapy success.

Give this medication with or without food, although giving with food may lessen any stomach upset.

Give medication as directed by your veterinarian. This medication is usually given once a day for several weeks.

Give the exact amount prescribed and only as often as directed. Occasionally, your veterinarian may change the dose to achieve the best results.

Ideally, give the medication at the same time daily.

Do not give your dog aged cheese while on fluoxetine.

It may take several weeks before effects of the medication are noted.

Do not abruptly discontinue this drug. It will be necessary to slowly taper the dose over time to reduce unpleasant side effects and ensure your pet's behavior does not return.

Baseline and periodic blood testing may be necessary to assess the pet's health and response to fluoxetine.

What if dose is missed?

If a dose is missed, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.

What to tell/ask veterinarian before giving medication?

Talk to your veterinarian about:

  • When will your pet need to be rechecked
  • What tests may need to be performed prior to and during treatment with this drug
  • Risks and benefits of using this drug

Tell your veterinarian about:

  • If your pet has experienced side-effects on other drugs/products
  • If your pet has experienced digestive upset now or ever
  • If your pet has experienced liver or kidney disease now or ever
  • If your pet has experienced any other medical problems or allergies now or ever
  • All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
  • If your pet is pregnant or nursing or if you plan to breed your pet
Storage and Warnings:

Store in a tight, light resistant, childproof container in a cool, dry place at room temperature away from heat and direct sunlight. Do not remove the desiccant, if included.

Keep this and all medication out of reach of children and pets. Call your physician immediately if you accidentally take this product.

Pet owners allergic to fluoxetine and/or other SSRIs should use caution when handling this drug.

Potential side effects:
  • Commonly, dogs lose their appetite, and subsequently lose weight. Tempt your dog with better tasting foods or hand feed until this side effect wears off. Report continued lack of appetite to your veterinarian.
  • Lethargy, drowsiness
  • Vomiting, diarrhea, shaking, restlessness, panting, irritability, excessive vocalization
  • Some dogs lose their inhibitions while medicated and become aggressive
  • Low chance of seizures
  • Liver disease has been reported. Monitor your pet for fatigue, lack of appetite as well as yellowing of the gums, skin, or the whites of the eyes. Your veterinarian may want to perform liver function blood tests.
  • If you notice anything unusual, contact your veterinarian
Can this drug be given with other drugs?
  • Yes, but possible interactions may occur with buspirone, cimetidine, diazepam, digoxin, encainide, flecainide, haloperidol, lithium, l-tryptophan, metoclopramide, perphenazine, phenylbutazone, phenytoin, propafenone, thioridazine, tricyclic antidepressants (ex. amitriptyline, clomipramine, imipramine) and warfarin.
  • Fluoxetine should not be used within 14 days of administering MAOIs (ex. amitraz, deprenyl, isoniazid, selegiline)
  • Fluoxetine should not be given with drugs that could increase the likelihood of seizures (ex. acepromazine, chlorpromazine)
  • If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian
Overdosing?

Contact your veterinarian immediately if pet consumes more than the prescribed amount.

What else should I know?

Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.

As with all prescribed medicines, fluoxetine should only be given to the dog/cat for which it was prescribed. It should be given only for the condition for which it was prescribed.

This is just a summary of information about fluoxetine. If you have any questions or concerns about fluoxetine or for the condition it was prescribed, contact your veterinarian.

Fluoxetine Hydrochloride
(Reconcile, Prozac)

Common Drug Name
Fluoxetine Hydrochloride

Common Brand Names
Reconcile (veterinary form) Prozac (human form)
Generic veterinary products are not available.

Storage
Store at room temperature in a tight, light resistant, childproof container. Do not remove the desiccant, if present. 

Uses
Fluoxetine is in a class of drugs called selective serotonin inhibitors (SSRIs). It is used to treat separation anxiety in dogs in conjunction with a behavior modification plan. It may also be used to treat other behavior problems including obsessive- compulsive behavior such as constant licking in dogs and cats, and feather picking in birds. It may also be used to treat inappropriate elimination in cats.
It may take 1-4 weeks before you see an effect.

Dose and Administration

Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.
Fluoxetine may be given with food to help prevent stomach upset.
If using the transdermal gel, apply to the skin as directed by your veterinarian.
Do not suddenly stop giving the medication unless advised by your veterinarian.
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give 2 doses at once.
This medication should only be given to the pet for whom it was prescribed.

Possible Side Effects
The most common side effect is loss of appetite, which is usually temporary. Try feeding your pet by hand, offering more flavorful foods, or, for dogs and cats, slightly warming canned foods. If your pet is on a special diet because of a medical condition, consult your veterinarian before changing or adding other foods. Also consult your veterinarian if your pet’s appetite does not return to normal.
May also see weight loss, lethargy, vomiting, shaking, diarrhea, restlessness, excessive vocalization, anxiety, panting, sleep disturbances, hyperactivity, and irritability. In dogs may also see panting. In cats may also see changes in elimina­tion patterns. Consult your veterinarian if you notice any of the above side effects.
Fluoxetine may cause aggression in some dogs. If this occurs, contact your veterinarian immediately.
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Precautions
Not for use in animals hypersensitive (allergic) to fluoxetine or other SSRIs, such as sertraline (Zoloft) or paroxetine (Paxil).
The safety of using fluoxetine in pregnant animals has not been determined. Do not use in lactating animals (female animals nursing their young), since the drug enters the breast milk.
Do not use in animals with a history of epilepsy or seizures.
Use with caution in animals with liver disease and in diabetic animals since fluoxetine may alter blood sugar levels.
Consult with your veterinarian regarding the physical examinations and laboratory testing necessary prior to and during treatment with fluoxetine.

Drug, Food, and Test Interactions
Notify your veterinarian of any other medications, including vitamins and supplements, your pet is taking while your pet is receiving fluoxetine.
Do not use with ephedrine or monoamine oxidase inhibitors (MAOIs) such as isoniazid, selegiline (deprenyl, Anipryl) or amitraz (an ingredient in some tick collars, and in Mitaban, a treatment for mange). These products need to be discontinued for 2-5 weeks before fluoxetine can be safely given. Consult your veterinarian before using other medications or tick collars along with fluoxetine.
Consult your veterinarian before using fluoxetine with warfarin, phenylbutazone, and digoxin, L-tryptophan, diazepam (Valium), buspirone, clomipramine (Clomicalm) and other tricyclic antide­pressants (such as amitriptyline), or meto­clopramide, since interactions may occur. 

Signs of Toxicity/Overdose
May see behavior changes, tremors, seizures, or liver disease, with vomiting. If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.
Keep this and all other medications out of the reach of children and pets.

This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times.  Always consult your own veterinarian for specific advice concerning the treatment of your pet.


 
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