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Equimax

Equimax by Bimeda

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Equimax® Paste

Generic Name:

Equine Ivermectin + Praziquantel


General Parasite Control Description:

Implementing effective parasite control is an important part of your horse's preventative health program as they can infect horses at any age and adversely affect health and performance. Parasite eggs and larvae are in your horse's environment and can remain viable for years despite harsh weather conditions. Internal parasites are commonly found in horses that appear healthy and infected animals continue to contribute to the spread of eggs in the environment. Parasite infestation can cause a loss of condition, lethargy, loss of appetite, poor coat, weight loss, diarrhea, and colic. While they undergo different stages of maturation, parasites can vary in anatomic location from the intestinal tract to other tissues in the horse. Each antiparasitic drug will vary in its effectiveness in targeting different stages of the parasite's life cycle.

What is this drug?
  • This is a combination broad spectrum oral antiparasitic drug containing ivermectin and praziquantel. Ivermectin interferes with neurotransmission causing paralysis and death of parasites and praziquantel increases calcium in the tapeworm which causes paralysis and an inability to attach to the intestines.
Reasons for prescribing:
  • Ivermectin is effective in the treatment and control of the following parasite infections in healthy horses:
    • Strongyles - redworms
      • Eggs are passed by infected horses onto the grass which develop into infective larvae. The horse eats the larvae from the contaminated grass and they undergo several stages of maturation within the intestines and can cause irritation, damage, and colic in certain circumstances.
      • Specifically targets large strongyles:
        • Strongylus vulgaris (adult and early blood vessel stage)
        • Strongylus edentatus (adult stage)
        • Triodontophorus brevicauda (adult stage)
        • Triodontophorus serratus (adult stage)
        • Craterostomum acuticaudatum (adult stage)
  • Specifically targets small strongyles:
    • Cyathostomum spp (adult stage)
    • Cylicostephanus spp (adult stage)
    • Cylicocyclus spp (adult stage)
    • Coronocyclus spp (adult stage)
    • Cylicodontophorus sp (adult stage)
    • Petrovinema poculatus (adult stage)
    • Encysted cyathostomes (L4 larval stages)
  • Ascarids - roundworms
    • Eggs are passed by infected horses onto the grass which develop into infective larvae. The horse eats the larvae from the contaminated grass and they undergo several stages of maturation within the intestines and can cause irritation, damage, and colic in certain circumstances.
    • Specifically targets:
      • Parascaris equorum (adult and L4 larval stage)
  • Lungworm
    • Eggs are passed by infected horses onto the grass which develop into infective larvae. The horse eats the larvae from contaminated grass and they migrate to the lungs and mature. In the airways, adult worms cause inflammation which leads to a cough and other respiratory problems. Adult females lay eggs that are coughed into the mouth, swallowed into the stomach, and passed into the feces.
    • Specifically targets:
      • Dictyocaulus arnfieldi (adult and L4 larval stage)
  • Intestinal Threadworm
    • Is primarily a concern for foals where the infective larvae enters the foal's system through drinking infected milk from the mare. The larvae migrate through the lungs and small intestines and can cause indigestion and diarrhea.
    • Specifically targets:
      • Strongyloides westeri (adult stage)
  • Neck Threadworm
    • Requires biting insects for the spread of immature threadworms. Once the parasite enters the skin, it travels to connective tissue in the neck as well as certain tendons and ligaments in the legs. The adult then produces an immature form of the parasite which travels back to the skin causing an itchy and allergic type reaction. The resultant skin lesions attract further insects which continue to transmit the parasite to other horses.
    • Specifically targets:
      • Onchocerca spp (microfilariae)
  • Bots
    • Adult flies lay eggs on the horse in the summer. The horse ingests the infective eggs during grooming which causes the eggs to hatch and the larvae to enter the mouth. The larvae migrate to the intestines and can cause irritation and damage.
      • Specifically targets:
        • Gasterophilus intestinalis (oral and stomach stage)
        • Gasterophilus nasalis (oral and stomach stage)
  • Hairworms
    • Eggs are passed by infected horses onto the grass which develop into infective larvae. The horse eats the larvae from the contaminated grass and they mature into adult worms in the stomach where they can cause irritation and damage to the stomach lining.
    • Specifically targets:
      • Trichostrongylus axei (adult stage)
  • Pinworms
    • Larvae mature in the large intestines and adult worms migrate and live in the colon. The female deposits eggs around the anus which causes skin irritation. Horses commonly have a roughened tail head from rubbing against objects.
    • Specifically targets:
      • Oxyuris equi (adult and L4 larval stage)
  • Stomach worms
    • Adult flies lay eggs on the horse in the summer. The horse ingests the infective eggs during grooming which causes the eggs to hatch and the larvae to enter the mouth. The larvae migrate to the intestines and can cause irritation and damage. A serious skin condition can develop if the larvae migrate into open sores on the skin or into the moist areas around the eyes.
    • Specifically targets:
      • Habronema muscae (adult stage)
  • Summer sores
    • Biting insects such as the common house fly and stable fly can carry infective worm larvae. Once into the skin, the horse has an allergic type reaction to the larvae and this can manifest as a chronic skin condition in the summer months due to the intense itching.
    • Specifically targets:
      • Habronema muscae (cutaneous L3 larval stage)
      • Draschia spp (cutaneous L3 larval stage)
  • Praziquantel is effective in the treatment and control of the following parasite infections in healthy horses:
    • Tapeworm
      • Eggs are passed by infected horses onto the grass which are then eaten by a mite. The larvae develop inside the mite which lives in the soil, grass, hay, and straw. The horse eats the infected mite from the contaminated food source. The larvae undergoes several stages of maturation within the intestines and can cause irritation, damage and colic in certain circumstances.
      • Specifically targets:
        • Anoplocephala perfoliata (adult stage)
What horses should not take this medication?
  • Consult the product insert regarding specific age recommendations for younger horses
  • Horses that are sick, debilitated, or underweight
  • Horses with a known hypersensitivity or allergy to this drug
Directions:

You need to accurately determine the weight of the horse with a scale or a weight tape prior to administration of this drug as the dose is based on the weight of the horse. Inadequate dosing will be ineffective and can encourage drug resistance. If you are unsure how your horse will react to oral administration of a medication, request assistance or demonstration by your veterinarian.

Administration using an oral dosing syringe:
  • Accurately determine the weight of the horse
  • Dial the correct dose on the product syringe
  • Ensure there is no feed in the mouth
  • Remove cap from product syringe
  • Place the tip of the syringe in the side of the horse's mouth in the space between the teeth
  • Gently push the plunger and deposit the medication on the back of the tongue
  • Remove the product syringe from the mouth
  • Raise the head slightly and ensure that the medication is swallowed
  • If product syringe is empty
    • Dispose of the product syringe and contents in approved landfill or incinerate as the ivermectin component can be lethal to aquatic life
  • Partially used product syringes
    • Store properly with the cap secured tightly
  • Wash hands after use
What is an effective parasite control program?

Parasite resistance is a current threat to effective parasite management. Talk to your veterinarian about developing a selective and responsible deworming strategy for your horses.

What to tell/ask your veterinarian before giving this medication?
 
Talk to your veterinarian about:
  • The benefits of doing a fecal egg count
  • Number of animals on your premises
  • Parasite prevalence in your geographic location
  • Health status of the horses on your property
  • Movement of animals on and off your property
  • Plans for breeding and if your horse is pregnant
  • If your horse has experienced any other medical problems or allergies
Storage and Warnings:

This product should be stored at room temperature and protected from freezing.
Avoid having this product released into the ground or free-running water.
This product can cause severe reactions in other species, keep this and all medication out of reach of children and other pets.
Avoid contact with skin, wash hands and contaminated skin with soap and water.
If accidental contact with eyes occurs, flush repeatedly with water.
Call your physician immediately if you accidentally take this product or in case of contact with eyes.

Potential side effects:
  • Adverse reactions are uncommon at recommended doses
  • This medication can cause adverse reactions with overdosages
    • Use caution when administering this medication to foals and miniature horses
    • Signs of toxicity may include visual impairment, depression and incoordination
  • This medication may cause swelling or itching after treatment in horses with heavy neck threadworm infestations
Can this drug be given with other drugs?
  • Avoid concurrent use of benzodiazepines
  • Do not give new medications without first talking to your veterinarian
  • If your horse experiences any unusual reactions when taking multiple medications, contact your veterinarian
Overdosing?

Contact your veterinarian immediately if you have accidentally given more than the prescribed amount.

What else should I know?

Notify your veterinarian if your animal experiences any adverse reactions to this medication.

Do not use this product in dogs or cats.

This product should not be used in horses or ponies intended for human consumption.

Check with the appropriate regulatory body regarding the use in competition horses.

As with all prescribed medication, Equine Ivermectin and Praziquantel should only be given to the horse for which it was prescribed and any medication given should be properly documented for that individual.

This is just a summary of information about Equine Ivermectin and Praziquantel. If you have any questions or concerns about this product or the parasites it prevents, please contact your veterinarian.

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