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Enalapril Maleate

Enalapril Maleate by Wockhardt

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Enalapril maleate

Trade Names:


General Description:

This drug is a medication that is used in dogs and cats to dilate blood vessels which helps the heart to work more efficiently. Enalapril maleate is available in the form of tablets.

 What is this drug?
  • An angiotensin converting enzyme inhibitor
  • Given by mouth
 Reasons for prescribing:
  • To treat heart failure
  • To treat high blood pressure
 What dogs/cats should not take this medication?
  • Animals with liver disease
  • Animals with blood disorders
  • Animals with certain kidney disease
  • Animals with certain vascular disease
  • Animals that are dehydrated
  • Animals that may be pregnant or nursing
  • Animals with a known hypersensitivity or allergy to this drug should not take this medication

Read and follow the prescription label carefully.

Give the exact amount prescribed and only as often as directed.

Discuss with your veterinarian if this medication is to be given with food.

Give this medication for as long as your veterinarian directs. Do not skip doses or stop giving the medication without consulting your veterinarian.

Baseline blood work is recommended to assess your pet's general health before starting this medication.

Periodic blood work, chest radiographs, and urinalysis may be recommended to monitor enalapril maleate's effects on the body as long term therapy is often necessary. Dose adjustments may be made based upon these results and an assessment of how your dog or cats is responding clinically.

It is important that your pet does not become dehydrated while taking this medication, ensure that they have access to fresh water at all times.

Call ahead for refills.

Ideally, give this medication at the same time(s) daily.

 What if a dose is missed?

If a dose is missed, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.

 What to tell/ask a veterinarian before giving medication?

Talk to your veterinarian about:

  • When your pet will need to be rechecked
  • What tests may need to be performed prior to and during treatment with this drug
  • What are the risks and benefits of using this drug

Tell your veterinarian about:

  • If your pet has experienced side-effects on other drugs/products
  • If your pet has experienced digestive upset now or ever
  • If your pet has experienced liver or kidney disease now or ever
  • If your pet has experienced any other medical problems or allergies now or ever
  • All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medications can be given together.
  • If your pet is pregnant, nursing or if you plan to breed your pet
 Storage and Warnings:

Enalapril maleate should be stored in a childproof container in a cool, dry place at room temperature away from heat and direct sunlight.

Keep this and all medication out of reach of children and pets.

Consult with your veterinarian if you switch between different brands of enalapril maleate as monitoring your pet's condition may be required during this transition.

Call your physician immediately if you accidentally take this product.

 Potential side effects:
  • This medication can affect the gastrointestinal system causing decreased appetite, vomiting, diarrhea, and weight loss
  • This medication can affect the kidneys causing increases in thirst and urination
  • This medication can affect the levels of potassium in the blood causing a slow heart rate and weakness
  • This medication can cause low blood pressure causing lethargy and weakness
  • If these symptoms persist or you notice anything else unusual, contact your veterinarian
 Can this drug be given with other drugs?
  • Yes, but possible interactions may occur when giving enalapril maleate in conjunction with: digoxin, diuretics (ex. furosemide, spironolactone), nonsteroidal antiinflammatories (ex. acetaminophen, deracoxib, carprofen, ibuprofen, meloxicam), and potassium supplements
  • Drugs other than those listed may also interact with enalapril maleate
  • Do not give new food or medications without first talking to your veterinarian
  • If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian

Contact your veterinarian immediately if your pet receives more than the prescribed amount.

 What else should I know?

Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.

As with all prescribed medicines, enalapril maleate should only be given to the pet for which it was prescribed.

It should be given only for the condition for which it was prescribed.

 This is just a summary of information about enalapril maleate. If you have any questions or concerns about enalapril maleate or the condition it was prescribed for, please contact your veterinarian.


(Enacard, Vasotec)

Common Drug Name

Common Brand Names
Enacard, Vasotec (human form)
Generic products are available.

Refrigerate oral suspension. Store other forms at room temperature (less than 86°F) in a tightly closed, childproof container, protected from moisture.
Do not remove the desiccant.

Enalapril is in the class of drugs called ACE inhibitors. It dilates the veins and decreases fluid retention. It is used in dogs, cats, and ferrets for the treatment of heart failure, dilated cardiomyopathy, and high blood pressure. It is also sometimes used in the treatment of some types of chronic renal failure. Results should be seen within about 2 weeks.

Dose and Administration
Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.
Give the oral form by mouth, with or without food.
If using the transdermal gel, apply to the skin as directed by your veterinarian.
Do not abruptly start or stop this medication without approval by your veterinarian.
Treatment is normally continued for the duration of the animal's life.
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give 2 doses at once. 
This medication should only be given to the pet for whom it was prescribed.

Possible Side Effects
Most commonly may see loss of appetite, vomiting, diarrhea, listlessness, and incoordination. May also see low blood pressure, which may cause weakness or collapse; kidney dysfunction, which may cause increased thirst and/or changes in urination; and abnormally high potassium levels, which may cause weakness, a slow heart rate, and a weak pulse. Contact your veterinarian if your pet has any of these signs.
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Do not use in animals who are hypersensitive (allergic) to this drug or other ACE inhibitors.
Not for use in pregnant and lactating animals (female animals nursing their young).
Use with caution in animals with kidney disease.
Animals with liver disease may not be able to properly convert the medication to its active form.
Switching from the veterinary to human brand of enalapril may require additional monitoring. Contact your veterinarian. Consult your veterinarian regarding the physical examinations and laboratory testing needed prior to and during the use of this medication.

Drug, Food, and Test Interactions
Consult your veterinarian before using enalapril with any other medications, including vitamins and supplements, diuretics (e.g. Lasix, Salix), other vaso­dilators, non-steroidal anti-inflammatory drugs (NSAIDs) e.g., aspirin, etodolac (EtoGesic), carprofen (Novox or Rimadyl), meloxicam (Metacam, firocoxib (Previcox), tepoxalin (Zubrin), or deracoxib (Deramaxx), since interactions may occur. 
This medication is commonly given along with diuretics such as furosemide (Lasix, Salix), and may require adjustment of the diuretic dose by your veterinarian.
It is important your pet does not become dehydrated while taking enalapril. Make sure your pet has access to clean drinking water while taking this medication.
High potassium levels may develop if potassium supplements, or potassium-sparing diuretics, are given at the same time as enalapril.

Signs of Toxicity/Overdose
The most common sign of an overdose is weakness. May also see any of the other side effects listed above. 
If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.
Keep this and all other medications out of the reach of children and pets.

This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times. Always consult your own veterinarian for specific advice concerning the treatment of your pet.

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