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Piroxicam

Piroxicam by Teva Pharmaceuticals

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Piroxicam is a non-steroidal anti-inflammatory drug (NSAIDs) that is commonly used for managing pain and inflammation in dogs. The action mechanism of Piroxicam is to hinder the secretion of prostaglandins, thereby bringing relief from fever, pain and inflammation. It could also be combined with other drugs in the treatment of transitional cell carcinoma- a type of bladder cancer in dogs.

Clinical results have proved that this drug is well tolerated by dogs, even though side effects might occur in rare cases. Stomach and intestinal ulcers, bleeding, dark stools, peritonitis, vomiting etc., are some of the common side effects. A few of these could be life threatening as well. Piroxicam can hamper the smooth functioning of kidneys which might lead to papillary necrosis. Piroxicam could also damage the natural blood clotting mechanism, thereby increasing the risks of bleeding.

Brand/Generic equivalents:
Feldene
 

Piroxicam
(Feldene)

Common Drug Name
Piroxicam

Common Brand Names
Feldene Generic products are available.

Storage
Store at room temperature in a tight, light resistant, childproof container.

Uses
Piroxicam is a non-steroidal antiinflammatoy drug (NSAID) that also has anti-tumor properties. It is most often used in pets for the treatment of certain types of cancers, especially bladder cancer.

Dose and Administration
Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian. Oral piroxicam is given by mouth. It may be given with food to reduce the chance of stomach/intestinal side effects. Piroxicam in the form of a transdermal gel should be applied to the skin as directed by your veterinarian. If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give 2 doses at once. This medication should only be given to the pet for whom it was prescribed.

Possible Side Effects

The most common side effects of NSAIDs, including piroxicam, are stomach bleeding and ulcers. Signs of these may include loss of appetite, vomiting, diarrhea, dark or tarry stools, bloody stools, or constipation. Side effects involving the kidney include increased thirst and increased urination. Side effects involving the liver include jaundice (yellowing of the gums, skin, or eyes). Other side effects may include pale gums, lethargy, shedding, hot spots, incoordination, seizures, or behavioral changes. If any of these side effects are observed, stop treatment and contact your veterinarian. Piroxicam may cause the blood to take longer to clot, so an animal may bleed longer from a cut or abrasion. If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Precautions
Not for use in animals who are hypersensitive (allergic) to carprofen, aspirin, etodolac (EtoGesic), deracoxib (Deramaxx), meloxicam (Metacam) or other NSAIDs. The safety of the drug has not been determined in breeding, pregnant, or lactating animals (female animals nursing their young). Consult with your veterinarian regarding the physical examinations and laboratory testing necessary prior to and during treatment with piroxicam. Use with extreme caution and continued monitoring in animals with dehydration or stomach, intestinal, kidney, liver, heart, clotting, or blood disorders. Use with extreme caution in cats.

Drug, Food and Test Interactions

Consult your veterinarian before using piroxicam with any other medications, including vitamins and supplements, other NSAIDs (e.g., aspirin, etodolac (EtoGesic), deracoxib (Deramaxx), meloxicam ((Metacam); steroids (e.g., prednisone, prednisolone, dexamethasone, triamcinolone); or phenylbutazone, oral anticoagulants (heparin, warfarin), cisplatin, and methotrexate, since interactions may occur. There is a greatly increased risk of stomach ulcers if used with non-steroidal anti-inflammatory drugs (NSAIDs).

Signs of Toxicity/Overdose
May see loss of appetite, vomiting, diarrhea, dark or tarry stools, bloody stools, increased thirst, increased urination, pale gums, jaundice (yellowing of gums, skin, or eyes), lethargy, increased respiration (fast or heavy breathing), incoordination, seizures, or behavioral changes. An overdose or toxicity could be fatal. If any of these reactions are observed, stop treatment and contact your veterinarian immediately. Keep this and all other medications out of the reach of children and pets.

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