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Clomicalm by Novartis Direct

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Clomicalm® Tablets

Generic Name:


General Description:

Clomipramine is a tricyclic antidepressant used to control various behavior problems in dogs (ex. separation anxiety, obsessive compulsive disorders, etc). It is primarily used in dogs, but with caution may be used in cats. Best results are achieved with most behavior drugs by simultaneous use of behavior modification training. Clomipramine is available in tablet or capsule form.

What is this drug?
  • A tricyclic antidepressant.
  • Given by mouth.
Reason for prescribing:
  • To reduce the signs of separation anxiety in dogs older than 6 months
  • To alleviate inappropriate barking or destructive behavior, obsessive compulsive disorders (ex. compulsive grooming, wool-sucking), dominance aggression as well as inappropriate elimination (urination or defecation)
  • Most often used in dogs, but may be used with caution in cats. Since a convenient dosage form is not available commercially for cats, it is often compounded at a special pharmacy.
What dogs/cats should not take this medication?
  • Dogs with known hypersensitivity to clomipramine or other tricyclic antidepressants (ex. amitriptyline).
  • Male breeding dogs, nursing mothers
  • Working dogs, as they may become too sedated to perform their duties
  • Use with caution in pets with a history of seizures, liver disease, cardiac disorders, glaucoma, thyroid disorders, urinary retention or reduced gastrointestinal function

May be administered as a single daily dose or divided twice daily. Divided doses may minimize side effects and will allow patients to adapt.

To reduce the incidence of vomiting, give with a small amount of food.

Avoid feeding cheese while pet is on Clomipramine.

Give medication as directed by your veterinarian. Read and follow the label carefully.

Give the exact amount prescribed and only as often as directed.

Give this medication for as long as your veterinarian directs. Call ahead for refills.

Ideally, give the medication at the same time daily.

What if dose is missed?

If a dose is missed, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.

What results should I expect?
  • Should be used as part of a comprehensive behavioral management program
  • Once desired response has been achieved, the dose may be tapered and/or discontinued as appropriate behavior has been learned
What to tell/ask veterinarian before giving medication?

Talk to your veterinarian about:

  • Signs of the condition your pet has
  • When will your pet need to be rechecked
  • What tests may need to be performed prior to and during treatment with this drug
  • Risks and benefits of using this drug

Tell your veterinarian about:

  • If your pet has experienced side-effects on other drugs/products
  • If your pet has experienced digestive upset now or ever
  • If your pet has experienced liver or kidney disease now or ever
  • If your pet has experienced any other medical problems or allergies now or ever
  • All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
  • If your pet is pregnant or nursing or if you plan to breed your pet
Storage and Warnings:

Store in a tight, light resistant, childproof container in a cool, dry place at room temperature.

People should not take this product. Keep this and all medication out of reach of children and pets. Accidental ingestion can be considered serious. Call your physician immediately if you accidentally take this product.

Potential side effects:
  • Lethargy, depression, increase or decrease in appetite, weight gain, vomiting, diarrhea, heart irregularities, tremors, elevation in liver enzymes
  • Increased drinking, dry mouth (frequent licking of lips), retention of urine and/or difficulty passing urine
  • Increased eye pressure (glaucoma)
  • May alter blood glucose levels
  • Cats are more sensitive than dogs to tricyclic antidepressant drugs
  • If you notice anything unusual, contact your veterinarian
Can this drug be given with other drugs?
  • Incompatible with monoamine oxidase inhibitors. Do not give in combination, or within
  • 14 days before or after treatment with these products: Anipryl®, isoniazid, Mitaban®, Preventic®, and ProMerisâ„¢ for dogs.
  • Use cautiously with antithyroid products, anticholergics, barbiturates, cimetidine, CNS depressants, fluoxetine, phenytoin or sympathomimetic products
  • Should not be given at the same time as drugs which lower the seizure threshold

An overdose situation can be life-threatening. The following signs have been reported: incoordination, heart irregularities, vocalization, seizure, collapse. Contact your veterinarian immediately if pet eats more than the prescribed amount.

What else should I know?

This is just a summary of information about clomipramine. If you have any questions or concerns about clomipramine or the condition it was prescribed for, contact your veterinarian.

As with all prescribed medicines, clomipramine should only be given to the dog/cat for which it was prescribed. It should be given only for the condition for which it was prescribed. It is important to periodically discuss your pet's response to clomipramine at regular check ups. Your veterinarian will best determine if your pet is responding as expected and if your pet should continue receiving clomipramine.


Common Drug Name

Common Brand Names
Clomicalm (veterinary product) Anafranil (human product)
Generic products are available.

Refrigerate oral suspension. Store other forms at room temperature in a tightly closed container.

Clomipramine is in the class of drugs called tricyclic antidepressants. To treat behavior problems, it should be combined with behavior modification techniques.
Dogs: Clomipramine is used for the treatment of obsessive-compulsive disorders, separation anxiety, and some types of aggression.
Cats: Clomipramine may be used to treat certain behavior problems, such as urine spraying, some types of aggression, or compulsive behaviors (grooming, wool-sucking).

Dose and Administration
Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.
Unless otherwise directed, give with food to help decrease the risk of gastrointestinal side effects.
If using the transdermal gel, apply to the skin as directed by your veterinarian.
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give 2 doses at once.
This medication should only be given to the pet for whom it was prescribed.  

Possible Side Effects
May see lack of appetite, vomiting, increased appetite and weight gain, diarrhea, lethargy, sleepiness, dry mouth, difficulty urinating, or increased heart rate. Contact your veterinarian if these side effects are severe or persistent.
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Not for use in animals hypersensitive (allergic) to clomipramine or other tricyclic antidepressants, such as amitriptyline.
Cats: May be more sensitive to the drug's side effects; use with caution.
Use with caution in animals with epilepsy, seizures, urine retention (problems urinating), decreased stomach/intestinal motility, constipation, liver or kidney disease, heart rhythm disturbances, thyroid disease, or glaucoma.
The safety of the drug has not been determined in pregnant, or lactating dogs and cats (female animals nursing their young). Do not use in males used for breeding.
Do not use in working animals (military dogs, police dogs, seeing eye dogs, hearing dogs, etc.) as it may cause too much sedation.
Consult with your veterinarian regarding the physical examinations and laboratory testing necessary prior to and during treatment with clomipramine.
Human Precautions
NOTE: Children are very sensitive to the seizure-inducing and heart effects of this medication. 

Drug, Food, and Test Interactions
Consult your veterinarian before using clomipramine with vitamins and supplements, monoamine oxidase inhibitors (MAOIs), such as selegiline (Anipryl), isoniazid, or amitraz (an ingredient in some tick collars, and in Mitaban, a treatment for mange), flea and tick collars, insulin, other antidepressant drugs, other drugs with anticholinergic effects (such as atropine), methimazole, other antithyroid drugs, fluoxetine, ketoconazole, or itraconazole, or cimetidine, since interactions may occur.
Clomipramine may alter blood glucose levels. 

Signs of Toxicity/Overdose
May have life-threatening reactions, such as seizures, heart arrhythmias, and heart failure, which may result in weakness, collapse, rapid breathing, or pale gums.
If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.
Keep this and all other medications out of the reach of children and pets.

This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times. Always consult your own veterinarian for specific advice concerning the treatment of your pet.

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