Enrofloxacin is an oral fluoroquinolone antibiotic used to treat various bacterial infections in dogs and cats (ex. urinary tract, respiratory, skin and soft tissue infections). Enrofloxacin should be given on an empty stomach. Enrofloxacin is available in tablets and 'taste tabs' in several different strengths.
What is this drug?
Enrofloxacin is a fluoroquinolone antibiotic
Given by mouth
Reasons for prescribing:
Often used in: bladder, ear, respiratory, skin and soft tissue infections
Effective against many bacteria types with fewer side effects than aminoglycoside type of antibiotics
What dogs/cats should not take this medication?
Young, growing animals due to potential for cartilage abnormalities
Use with caution in animals with liver or kidney conditions, or those suffering dehydration
Should not be used at high doses in cats (may cause blindness)
Breeding, pregnant or nursing animals
Pets who have a history of seizures or other central nervous system disorders
Pets known to have had an allergic reaction to other quinolones and/or sulfonamides
Enrofloxacin tablets are enteric coated to hide the natural bitter taste. Hiding crushed tablets in the pet's food will likely not be effective. Flavored tabs are available as a more palatable alternative. After administration, watch the pet closely to ensure the entire dose was consumed.
Give on an empty stomach.
Give enrofloxacin 2 hours before or after any iron, dairy or calcium products.
Ensure there is water available for your pet to drink.
Give medication as directed by your veterinarian. This medication is usually given one or two times daily.
Read and follow the label carefully.
Give the exact amount prescribed and only as often as directed. Missed doses reduce the effectiveness of therapy. Finish the entire course of treatment.
Ideally, give the medication at the same time daily.
What if dose is missed?
If a dose is missed, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.
What to tell/ask veterinarian before giving medication?
Talk to your veterinarian about:
When will your pet need to be rechecked
What tests may need to be performed prior to and during treatment with this drug
Risks and benefits of using this drug
Tell your veterinarian about:
If your pet has experienced side-effects on other drugs/products
If your pet has experienced digestive upset now or ever
If your pet has experienced liver or kidney disease now or ever
If your pet has experienced any other medical problems or allergies now or ever
All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
If your pet is pregnant or nursing or if you plan to breed your pet
Storage and Warnings:
Store tablets in a tight, light resistant, childproof container in a cool, dry place at room temperature away from heat and direct sunlight.
People should not take this drug. Keep this and all medication out of reach of children and pets. Call your physician immediately if you accidentally take this product.
Pet owners who are allergic to quinolones (such as ciprofloxacin or norfloxacin) should avoid handling this drug.
Potential side effects:
Nausea, vomiting and diarrhea (dogs/cats on high doses)
Excessive thirst, decrease in appetite
Damage to joint cartilage in dogs <8 months of age
Urine crystals in dehydrated pets
May worsen existing obsessive behaviors
Rare incidences of dizziness, seizures, depression, lethargy and nervousness
Rare incidences in cats of vocalizing, aggression and dilated pupils
If you notice anything unusual, contact your veterinarian
Can this drug be given with other drugs?
Yes, but possible interactions may occur with aminoglycosides, antacids, 3rd generation cephalosporins, clindamycin, nitrofurantoin, oral cyclosporine, probenecid, sucralfate, theophylline and medications containing aluminum, calcium, iron and magnesium.
If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian
Contact your veterinarian immediately if pet eats more than the prescribed amount.
What else should I know?
Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.
As with all prescribed medicines, enrofloxacin should only be given to the dog/cat for which it was prescribed. It should be given only for the condition for which it was prescribed.
This is just a summary of information about enrofloxacin. If you have any questions or concerns about enrofloxacin or the condition it was prescribed for, contact your veterinarian.
Common Drug Name
Common Brand Names
No generic products are available.
Store in a tight, light resistant, childproof container between 40-86°F.
Enrofloxacin is an antibiotic of the quinolone class.
Dogs and Cats: It is used in the treatment of susceptible bacterial infections.
Ferrets, Rabbits, Hedgehogs, Chinchillas, Hamsters, Gerbils, Guinea Pigs, Mice, Rats: Enrofloxacin may be used to treat bacteria and mycoplasma infections.
Reptiles: Injectable enrofloxacin may be used to treat bacteria infections, especially of the respiratory system.
Dose and Administration
Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.
Dogs: The nonchewable tablet may be placed in food or given by hand (“pilled”).
Cats: The tablet should be given by hand.
The tablet is bitter and may cause your pet to salivate or refuse treatment. Do not crush the tablet. Monitor after giving the medication orally to be sure all of it was consumed.
Use all of the medication prescribed. If the entire course of treatment is not given, the infection may recur or worsen.
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give 2 doses at once.
This medication should only be given to the pet for whom it was prescribed.
Possible Side Effects
May see lack of appetite, vomiting, diarrhea, dilated pupils (in cats), and seizures in animals with central nervous system (CNS) disorders, such as epilepsy. May also see depression, dizziness, nervousness, or other behavior changes. If you observe any of these signs, contact your veterinarian.
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.
Do not use in animals hypersensitive (allergic) to it or other quinolone antibiotics and/or sulfonamides.
Cats: Use with caution. Do not exceed 2.2 mg/pound per day. Higher doses can result in altered vision or blindness.
The safe use of enrofloxacin in breeding animals or pregnant or lactating animals (female animals nursing their young) has not been evaluated.
May cause problems in the development of bones/joints of young growing animals, including large breeds of dogs under 24 months. Only use in growing animals, if under the supervision of a veterinarian.
Do not use in animals with central nervous system (CNS) disorders, such as epilepsy, as it could possibly cause seizures. Use with caution in pets with liver or kidney disease.
In pets taking enrofloxacin, dehydration increases the risk of seizures and crystals developing in the urine. Make sure your pet has access to clean drinking water while taking this medication.
Enrofloxacin causes hallucinations in people, and may worsen signs in animals with obsessive behaviors.
People with hypersensitivities (allergies) to quinolone antibiotics, such as ciprofloxacin or norfloxacin, should not handle the medication, since a photosensitivity reaction could occur just from contact.
Contact your veterinarian regarding physical examinations and laboratory testing necessary prior to and during treatment with enrofloxacin.
Drug, Food, and Test Interactions
Consult your veterinarian before using enrofloxacin with vitamins and supplements, probenecid, oral cyclosporine, since interactions may occur.
Do not use within 2 hours of giving antacids, sucralfate, or iron, aluminum, calcium, or dairy products, as absorption will be decreased.
May cause increased theophylline blood levels.
Signs of Toxicity/Overdose
May see lack of appetite, vomiting, or diarrhea, dizziness, dilated pupils or blindness (in cats), seizures in animals with central nervous system (CNS) disorders, such as epilepsy.
If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.
Keep this and all other medications out of the reach of children and pets.
This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times. Always consult your own veterinarian for specific advice concerning the treatment of your pet.