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Metoclopramide Oral Solution

Metoclopramide Oral Solution by Ani Pharmaceuticals

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General Description:

Metoclopramide is an affordable drug used in dogs and cats to prevent nausea, vomiting and esophageal reflux (stomach acid backing up into the throat). It helps move food and hairballs from the stomach into the intestines. It is also used during cancer chemotherapy to prevent vomiting and other side effects. Metoclopramide is available in 5 mg and 10 mg tablets or as an oral syrup, 1 mg and 10 mg/mL.

What is this drug?
• Upper gastrointestinal tract motility stimulant; anti-emetic
• May be given by injection in the veterinary clinic or may be given by mouth

Reasons for prescribing:
• To prevent nausea and vomiting by normalizing stomach motility
• Moves food and hairballs from the stomach into the intestines
• Prevent esophageal reflux (stomach acid backing up into the esophagus)
• Used after surgery and during cancer chemotherapy to prevent nausea and vomiting

What dogs/cats should not take this medication?
• Avoid using in pregnant or nursing pets
• Pets with pheochromocytoma (a rare adrenal tumor)
• Pets with a history of seizures. Metoclopramide may cause seizures in these pets.
• Pets suspected to have a stomach or intestinal obstruction, bleeding or perforation
• Use with caution in pets with kidney disease, diabetes or high blood pressure or recent stomach surgery
• If your pet has had an earlier allergic reaction to metoclopramide or like products (ex. PABA sunscreens)


Metoclopramide should be given 20-30 minutes before a meal. Give each dose with plenty of water.

Give the exact amount prescribed and only as often as directed. It is usually given three to four times a day .

Read and follow the label carefully.

Give this medication for as long as veterinarian directs. Do not skip doses or stop giving the medication without consulting your veterinarian.

Oral suspensions are available but are often unpalatable to pets.

Call ahead for refills.

Ideally, give the medication at the same time(s) daily.

What if a dose is missed?

If a dose is missed, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.

What to tell/ask veterinarian before giving medication?

Talk to your veterinarian about:
• When will your pet need to be rechecked
• What tests may need to be performed prior to and during treatment with this drug
• Risks and benefits of using this drug

Tell your veterinarian about:
• If your pet has experienced side-effects on other drugs/products
• If your pet has experienced digestive upset now or ever
• If your pet has experienced any other medical problems or allergies now or ever
• If your pet is pregnant or nursing or if you plan to breed your pet

Storage and Warnings:

Store in a tight, light resistant, childproof container in a cool, dry place at room temperature away from heat and direct sunlight.

Keep this and all medication out of reach of children and pets.

Metoclopramide is very similar to the sunscreen ingredient PABA. Humans allergic to sunscreens should avoid contact with metoclopramide.

Possible side effects:
• Animals predisposed to seizures may experience seizures. This should not happen in 'normal' animals.
• Drowsiness, or marked hyperactivity, frenzy and/or disorientation
• Constipation, behavior and attitude changes
• If you notice any of these symptoms or anything else unusual, discontinue metoclopramide and contact your veterinarian

Can this drug be given with other drugs?
• Yes, but possible interactions may occur with acetaminophen, aspirin/acetylsalicylic acid, atropine, cimetidine, cyclosporine, diazepam, digoxin, insulin, MAOIs (ex. Anipryl, Preventic Flea Collar), narcotic analgesics, phenothiazine tranquillizers (ex. acepromazine), probantheline bromide, sedatives and tetracycline.
• Since metoclopramide increases the movement of gastrointestinal contents, it can affect the absorption rates of many oral drugs
• If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian.


Contact your veterinarian immediately if pet eats more than the prescribed amount.

What else should I know?

Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.

As with all prescribed medicines, metoclopramide should only be given to the pet for which it was prescribed. It should be given only for the condition for which it was prescribed.

This is just a summary of information about metoclopramide. If you have any questions or concerns about metoclopramide or the condition it was prescribed for, contact your veterinarian.


Common Drug Name

Common Brand Names
Generic products are available.

Store at room temperature in a tight, light resistant, childproof container.

Metoclopramide is used to prevent vomiting and esophageal reflux (stomach acid backing up into the esophagus) in many animal species. It may aid in the treatment of hairballs in rabbits. It is also used to prevent side effects, such as vomiting, resulting from chemotherapy.

Dose and Administration
Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give 2 doses at once.
This medication should only be given to the pet for whom it was prescribed.

Possible Side Effects
The most common side effect is  constipation. May also see behavior and attitude changes such as disorientation and frenzy. Consult your veterinarian if you notice any of the above side effects.
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Not for use in animals hypersensitive (allergic) to metoclopramide.
Do not use in an animal who has a stomach or intestinal blockage, or bleeding into the stomach.
Do not use in an animal with a history of seizures. Metoclopramide could cause seizures.
Do not use in an animal with an adrenal tumor called a pheochromocytoma. It could result in a potentially fatal increase in blood pressure.
Use with caution in pregnant or lactating animals (female animals nursing their young). Metoclopramide can cross the placenta and enter the milk.
Consult with your veterinarian regarding physical examinations and laboratory testing necessary prior to and during treatment with metoclopramide. 

Human Precautions
NOTE: Since metoclopramide is chemically very similar to PABA, the sunscreen agent, it should not be handled by people allergic to PABA.

Drug, Food and Test Interactions
Consult your veterinarian before using metoclopramide with any other medications, including vitamins and supplements, since interactions may occur.
Because metoclopramide increases the movement of stomach and intestinal contents, it can affect the absorption of many oral drugs. 
Metoclopramide may change the insulin requirements of diabetic animals.
Sedatives and tranquilizers may increase the chance of behavior and attitude changes caused by metoclopramide.

Signs of Toxicity/Overdose
May see sleepiness, staggering, agitation, seizures, vomiting, and constipation.
If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.
Keep this and all other medications out of the reach of children and pets.

This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times.   Always consult your own veterinarian for specific advice concerning the treatment of your pet.


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