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PrednisTab [Prednisolone]

PrednisTab [Prednisolone] by Lloyd Labs

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PrednisTab®

Generic Name:

Prednisone, Prednisolone and Prednisolone Acetate

General Description:

An oral anti-inflammatory agent used to treat many inflammatory, auto-immune and allergy conditions plus many other diseases. Prednisone/prednisolone tablets are available through your veterinarian in many concentrations. For use in both dogs and cats.

What is this drug?
• Members of the glucocorticoid class of hormones. This type of steroid breaks down stored resources (fats, carbohydrates and proteins) so that they can be used as fuel at times of stress. Glucocorticoids are naturally produced by the adrenal glands to prepare the body metabolically for physical exercise and stress.
• Prednisone is activated by the patient's liver into prednisolone. These products are considered interchangeable, although some cats are not efficient at the conversion and do better on prednisolone
• Given by mouth

Reasons for prescribing:
• Used in dogs and cats as an anti-inflammatory for the relief of inflamed areas, to decrease swelling, redness, itching and allergic reactions
• Used to treat multiple conditions including Addison's disease, shock, spinal cord and brain disorders, insulin-secreting tumors or metabolic conditions associated with low blood sugar, some anemias, allergies, auto-immune disorders, certain types of colitis and kidney disease
• To reduce blood calcium
• Used in cancer chemotherapy

What dogs/cats should not take this medication?
• Animals with a systemic fungal infection
• Animals with some types of mange (mites)
• Pets who have had seizures in the past
• Pets with stomach ulcers, corneal ulcers, osteoporosis, high blood pressure, liver and kidney disease or congestive heart failure
• Pets with serious bacterial or viral infections or gastrointestinal ulceration(s)
• Pets with Cushing's disease should only receive this medication during very stressful events
• Do not use in pregnant animals or in breeding males
• Use with caution in very young animals and diabetics
• If your pet has had an allergic reaction to prednisone/prednisolone or like products before

Directions:

Read and follow the label carefully.

Give the exact amount prescribed and only as often as directed. If given just once daily, dogs usually receive glucocorticoid drugs in the morning, and cats receive it in the evening (this mimics their natural hormone cycles).

The prime objective of steroid therapy is to achieve a satisfactory degree of control with a minimum effective dose.

Your pet may start at a high dose and then have it reduced. Prednisone/prednisolone may be prescribed for several weeks or even months. Individualization of dosage and duration of treatment will depend upon your pet's reaction to this drug.

It is important that the dose be tapered to an every other day schedule once the condition is controlled so do not discontinue the drug abruptly.

Give oral forms with food to reduce the chance of stomach ulcers.

Periodic blood work to monitor this drug's effect may be required if your pet is undergoing long- term therapy.

Call ahead for refills.

What if a dose is missed?

If a dose is missed, give it as soon as you can, regardless of feeding status. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.

What to tell/ask veterinarian before giving medication?

Talk to your veterinarian about:
• When will your pet need to be rechecked
• What tests may need to be performed prior to and during treatment with this drug
• What are the risks and benefits of using this drug

Tell your veterinarian about:
• If your pet has experienced side-effects on other drugs/products
• If your pet has experienced digestive upset now or ever
• If your pet has experienced liver or kidney disease now or ever
• If your pet has experienced any other medical problems or allergies now or ever
• All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
• If your pet is pregnant or nursing or if you plan to breed your pet

Storage and Warnings:

Store in a tight, light resistant, childproof container in a cool, dry place at room temperature away from heat and direct sunlight.

Keep this and all medication out of reach of children and pets.

Call your physician immediately if you accidentally take this product.

Potential side effects:
• Most common side effects are increased thirst, appetite and urination. Your pet may have accidents and need to go outside or use the litter box more frequently. Discuss these side effects with your veterinarian as the dose may be lowered or another steroid could be selected.
• This medication causes the kidney to conserve salt. This could be a problem in patients with congestive heart failure or other patients who require sodium restriction
• May stunt growth if used in young, growing animals
• May lower seizure threshold and alter mood and behavior
• At high doses, this medication can cause birth defects early in pregnancy, be irritating to the stomach or cause higher than normal blood sugar levels
• If your pet has received high doses, it should not be vaccinated without your veterinarian's advice as the vaccine may not work or it may actually give your pet the disease you are trying to prevent
• Less common side effects include weight gain, insomnia, panting, diarrhea, vomiting, elevated liver enzymes, pancreatitis and behavior changes
• Serious side effects are not expected with routine use. When higher doses are used or if use is chronic (ie. longer than 4 months on an every other day schedule), the side effects and concerns become different. Watch for muscle loss, weakness, and the development of diabetes or Cushing's disease. Typical signs of these diseases are increased thirst, urination and appetite. Cushingoid pets may develop thin skin, poor hair coat and a 'pot belly'. Monitoring tests or changing therapy may be recommended.
• High doses may lead to immune system suppression, making your pet more susceptible to infections. Contact your veterinarian if your pet has a fever (over 103°F), painful or frequent urination, fatigue, sneezing, coughing or runny eyes
• If you notice anything unusual, contact your veterinarian

Can this drug be given with other drugs?
• Yes, but possible interactions may occur with amphotericin B, cyclosporine, cyclophosphamide, erythromycin, estrogens, furosemide, insulin, mitotane, NSAIDS (aspirin, carprofen, deracoxib, etc), phenobarbital, phenytoin, rifampin, some vaccines and thiazide.
• If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian.

Overdosing?

Contact your veterinarian immediately if pet eats more than the prescribed amount.

What else should I know?

Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.

As with all prescribed medicines, prednisone/prednisolone should only be given to the pet for which it was prescribed. It should be given only for the condition for which it was prescribed.

This is just a summary of information about prednisone/prednisolone. If you have any questions or concerns about prednisone/prednisolone or the condition it was prescribed for, contact your veterinarian.
 

Corticosteroids
(Prednisone, Triamcinolone, Dexamethasone)

Common Generic & Brand Names
Prednisolone: Solu-Delta-Cortef  Prednisone: Meticorten, Sterapred Dexamethasone: Azium, Decadron Methylprednisolone: Depo-Medrol; Medrol Triamcinolone: Cortalone, Vetalog
Corticosteroids are also referred to as glucocorticosteroids, glucocorticoids, or sometimes simply as steroids.

Storage
Store at room temperature, in tight, light resistant, childproof container.

Uses
Corticosteroids are hormones used for the treatment of multiple conditions including adrenal insufficiency (Addison's disease); inflammation; autoimmune diseases, such as lupus, pemphigus, and some anemias; allergies including atopy; asthma; some cancers; and certain types of colitis and kidney diseases (nephrotic syndrome). 

Dose and Administration
Always follow the dosage instructions provided by your veterinarian. If you have difficulties giving the medication, contact your veterinarian.  
Dosage depends on the product used. Your veterinarian may recommend starting at a higher dose and then reducing the dose every few days to a week.
If using the transdermal gel, apply to the skin as directed by your veterinarian.
If using an injectable form, use a new, sterile needle and syringe each time, and follow the proper technique, as directed by your veterinarian. Dispose of the needle and syringe according to local regulations.
If you miss a dose, contact your veteri­narian to determine the next dose.
This medication should only be given to the pet for whom it was prescribed.

Possible Side Effects
Side effects are usually dose dependent. If side effects occur, contact your veteri­narian, who may decrease the dosage, frequency, or type of corticosteroid.
The most common side effects are increased appetite, drinking, and urination. Your pet may have more ?accidents? and need to go outside or use the litter box more often.
Less common side effects include weight gain, panting, diarrhea, vomiting, and behavior changes.
Side effects of long-term use include muscle loss, weakness, and the develop­ment of diabetes or hyperadrenocorticism (Cushing's disease). The typical signs of these diseases are increased thirst, urination, and appetite. Animals with Cushing's disease may also develop thin skin, a poor hair coat, and a ?pot-belly.? Activation or worsening of hypothyroidism or pancreatis.
Immune system suppression may occur, especially on higher doses, making a pet more susceptible to infection. Contact your veterinarian if your pet has a fever (over 103° F), painful urination (a sign of urinary tract infection), tiredness, sneezing, coughing, or runny eyes.

Precautions
Not for use in animals with systemic fungal infections, some types of mange (mites), stomach ulcers, Cushing's disease, high blood pressure, kidney disease, or congestive heart failure.
Do not use in pregnant animals. May cause premature birth. Can cause birth defects in dogs, rabbits, and rodents.
If on long-term therapy, do not discontinue the drug abruptly. The dose needs to be tapered off over several weeks to allow the body to start making its own cortisol again.
May need to give additional steroids while tapering, if the animal is stressed.
May stunt growth if used in young, growing animals.
Consult with your veterinarian regarding the physical examinations and laboratory testing necessary prior to and during treatment with corticosteroids. 

Drug, Food, and Test Interactions 
Consult your veterinarian before using corticosteroids with vitamins and supplements, non-steroidal anti­inflammatory drugs (NSAIDs) such as aspirin, carprofen (Novox or Rimadyl), deracoxib (Deramaxx), etodolac (EtoGesic), meloxicam (Metacam),firocoxib (Previcox), tepoxalin (Zubrin); insulin, modified live vaccines, phenytoin, phenobarbital, rifampin, cyclosporine, estrogens, erythromycin, or mitotane, amphotericin B, furosemide, or thiazide, since interactions may occur.
Corticosteroids may cause abnormal levels of hepatic enzymes, thyroid hormone, cholesterol, and potassium in the blood, and can affect many laboratory tests. Make sure your veterinarian knows your pet is taking corticosteroids prior to testing.

Signs of Toxicity/Overdose
An acute overdose is unlikely to cause problems. A chronic overdose is likely to cause signs of Cushing's disease or diabetes mellitus; both diseases commonly cause increased urinating, drinking, and eating. Abruptly stopping long-term treatment may cause signs of Addison's disease, including vomiting, weakness, collapse and sudden death.
If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.
Keep this and all other medications out of the reach of children and pets.

This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times.  Always consult your own veterinarian for specific advice concerning the treatment of your pet.
 

 

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