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Metronidazole

Metronidazole by Watson Labs

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Metronidazole

Trade Names:
Flagyl®
Metrogel®
Protostat®

General Description:

Metronidazole is an oral antibiotic used in dogs and cats to kill some intestinal parasites, especially Giardia spp. It is also used to treat diarrhea and infections caused by anerobic bacteria. This medication has a bitter taste. Disguising it with food may help you administer this drug successfully. Metronidazole is available as an oral liquid or as tablets.

What is this drug?
• Metronidazole is an antibiotic and an antiprotozoal
• Metronidazole is given by mouth

Reasons for prescribing:
• Effective against certain protozoal infections, especially Giardia
• Used to treat colitis/inflammatory bowel disease
• Used to treat central nervous system and oral/dental infections
• Used as an anti-diarrhea medication
• Used sometimes in cancer radiotherapy

What dogs/cats should not take this medication?
• Pregnant or nursing animals
• Use with extreme caution in debilitated or geriatric pets or those with liver or kidney disease
• Pets known to have had an allergic reaction to metronidazole or like products before

Directions:

For liquids, shake well before accurately measuring the dose.

Give this medication with food. Because the tablets have a natural bitter taste, they should not be crushed or chewed as the pet will drool plus likely refuse future doses. After administration, watch the pet closely to ensure the entire dose was consumed.

Give medication as directed by your veterinarian. This medication is usually given once or twice daily. The length of therapy depends upon the disease condition as well as the pet's response to metronidazole.

Read and follow the label carefully.

Give the exact amount prescribed and only as often as directed. Missed doses reduce the effectiveness of therapy.

Give this medication for as long as your veterinarian directs. Finish the entire course of treatment.

Ideally, give the medication at the same time daily.

What if dose is missed?

If a dose is missed, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.

What to tell/ask veterinarian before giving medication?

Talk to your veterinarian about:
• When will your pet need to be rechecked
• What tests may need to be performed prior to and during treatment with this drug
• Risks and benefits of using this drug

Tell your veterinarian about:
• If your pet has experienced side-effects on other drugs/products
• If your pet has experienced digestive upset now or ever
• If your pet has experienced liver or kidney disease now or ever
• If your pet has experienced any other medical problems or allergies now or ever
• All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
• If your pet is pregnant or nursing or if you plan to breed your pet

Storage and Warnings:

Store tablets in a tight, light resistant, childproof container in a cool, dry place at room temperature away from heat and direct sunlight.

Oral liquids should be stored in the refrigerator. Shake well before using.

Keep this and all medication out of reach of children and pets. Call your physician immediately if you accidentally take this product.

Potential side effects:

Generally side effects are not seen unless the pet is taking a very high dose or for a prolonged period of time (months). Side effects seen are:
• Decrease in appetite, nausea, diarrhea
• Anemia
• Liver damage (yellowing of gums, eyes, skin)
• Blood in the urine
• Weakness, stumbling, knuckling of the paws, head tilt to one side, dilated pupils, bizarre back and forth movements of the eye (called nystagmus), or seizures (cats)
• If you notice anything unusual, contact your veterinarian

Can this drug be given with other drugs?
• Yes, but possible interactions may occur with cimetidine, oral blood thinners, phenobarbital, phenytoin, sedatives or tranquilizers, and products with alcohol as an ingredient.
• If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian

Overdosing?

Contact your veterinarian immediately if pet eats more than the prescribed amount.

What else should I know?

Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.

As with all prescribed medicines, metronidazole should only be given to the dog/cat for which it was prescribed. It should be given only for the condition for which it was prescribed.

Metronidazole normally has a strong sulfurous odor which may smell like cat urine.

This is just a summary of information about metronidazole. If you have any questions or concerns about metronidazole or for the condition it was prescribed, contact your veterinarian.
 

Metronidazole
(Flagyl)

Common Drug Name
Metronidazole

Common Brand Names
Flagyl, Metizol, Protostat, Metrogel
Generic products are available.

Storage
Refrigerate oral suspension. Store other forms at room temperature in a tight, light resistant, childproof container.
Oral liquids should be shaken well before use and stored in the refrigerator.

Uses
Metronidazole is an antibiotic and antiprotozoal medication. It is used for the treatment of many types of infections, including one-celled intestinal parasites such as Giardia, in a variety of animal species.

Dose and Administration
Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.
Duration of treatment depends on reason for and response to treatment.
Tablets are given by mouth and may have fewer side effects if given with food.
The tablet is bitter and may cause your pet to salivate or refuse treatment. Do not crush the tablet. Monitor after giving the medication orally to be sure all of it was consumed. 
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give 2 doses at once. 
This medication should only be given to the pet for whom it was prescribed. 

Possible Side Effects
If the pill has prolonged contact with the mouth or is crushed or chewed, it may cause excessive salivation and pawing at the mouth.
Side effects include nausea, loss of appetite, vomiting, diarrhea, lethargy, weakness, anemia, blood in the urine, head tilt, seizures, disorientation, and stumbling. It may also cause liver disease, which can result in yellowing of the gums, skin, and eyes. Damage to nerves is also possible, and may result in the animal stumbling or knuckling over on the paws. If you notice any of these side effects, contact your veterinarian immediately.
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Precautions
Not for use in animals hypersensitive (allergic) to the drug or its derivatives.
Metronidazole can cause birth defects in some species. Not for use in debilitated, pregnant, or lactating animals (female animals nursing their young) unless benefits outweigh the risks.
Use with extreme caution in debilitated animals or those with liver or kidney disease.
Consult with your veterinarian regarding physical examinations and laboratory testing necessary prior to and during treatment with metronidazole.  

Drug, Food and Test Interactions
Consult your veterinarian before using metronidazole with any other medications; including vitamins and supplements, oral anticoagulants, cimetidine, phenobarbital, phenytoin, sedatives or tranquilizers since interactions may occur.
It may increase the blood levels of phenytoin.
No known food interactions.

Signs of Toxicity/Overdose
Signs of toxicity can occur with acute overdoses or long-term use. Signs include lack of appetite, vomiting, stumbling, nystagmus (eyes move rapidly back and forth), knuckling over at the joints, disorientation, stiffness, rigidity, and seizures. 
Signs may not resolve until the pet is off of the medication for several days.
If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.
Keep this and all other medications out of the reach of children and pets.

This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times.  Always consult your own veterinarian for specific advice concerning the treatment of your pet.
 

 

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