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Lysodren

Lysodren by Bristol Myers Squibb

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Lysodren®

Generic Name:

Mitotane

General Description:

Mitotane stops the growth of cells in the adrenal gland. It is used in treatment of Cushing's disease in dogs and also to treat some types of cancer affecting the adrenal gland. Pregnant women, or those wishing to conceive should not handle this drug. It is available in 500 mg scored tablets.

What is this drug?
• An adrenocortical cytotoxicant
• Given by mouth

Reasons for prescribing:
• For the treatment of hyperadrenocorticism (Cushing's disease) in dogs
• For treatment of some types of cancer affecting the adrenal cortex

What dogs/cats should not take this medication?
• Use with caution in pets with diabetes, liver or kidney disease
• Pregnant or nursing dogs
• If your pet has had an allergic reaction to mitotane or like products before

Directions:

Read and follow the label carefully.

Wear gloves when handling this medication. Wash hands well after handling this drug.

Give the exact amount prescribed and only as often as directed. Give mitotane with a fatty or oily meal (to increase absorption). Mitotane powders and liquids sprinkled on food with a little corn oil is an effective way to give the drug. But if your dog has been well-managed on whole tablets, switching to a liquid or powder, or giving a crushed tablet, could dramatically increase the amount of active ingredient that enters the bloodstream. Do not switch forms unless under close supervision by your veterinarian.

Your pet will receive high doses for the first 1-2 weeks, and then the dose will be lowered under the direction of your veterinarian.

Mitotane decreases the body's ability to handle stress. Glucocorticoids (ex. prednisone) may be prescribed for use during stressful situations (ex. travel, surgery, house guests, new baby, etc.).

Expect to see the signs of hyperadrenocorticism (lethargy, increased drinking, eating, or urination) improve within the first 2 weeks of treatment. Skin and hair loss changes may take several months to improve.

What if a dose is missed?

If a dose is missed, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.

What to tell/ask veterinarian before giving medication?

Talk to your veterinarian about:
• When will your pet need to be rechecked
• What tests may need to be performed prior to and during treatment with this drug
• What are the risks and benefits of using this drug

Tell your veterinarian about:
• If your pet has experienced side-effects on other drugs/products
• If your pet has experienced digestive upset now or ever
• If your pet has experienced anemia, liver or kidney disease now or ever
• If your pet has experienced diabetes or any other medical problems or allergies now or ever
• All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
• If your pet is pregnant or nursing or if you plan to breed your pet

Storage and Warnings:

Store in a tight, light resistant childproof container at room temperature away from heat and direct sunlight.

Keep this and all medication out of reach of children and pets. Do not handle this product if you are pregnant or trying to conceive.

Wear gloves when handling this medication. Wash hands well after handling this drug. It can be very toxic. Do not allow mitotane to enter the environment through the soil or water. Return any leftover drug to your veterinarian for proper disposal.

Call your physician immediately if you accidentally take this product.

Potential side effects:
• Most common effects: lethargy, weakness, loss of appetite, incoordination, depression, vomiting and diarrhea. Mitotane must be given in high doses until it starts to work. Most dogs will have an effect within 2-35 days, whereby the dose can be reduced from twice daily to twice a week. If your pet becomes unusually tired or weak, contact your veterinarian immediately.
• Possible liver damage (loss of appetite, yellowing of gums, eyes or skin) especially in pets with a pre-existing liver condition
• If you notice anything unusual, contact your veterinarian

Can this drug be given with other drugs?
• Yes, but possible interactions may occur with barbiturates, CNS depressants (ex. acepromazine, amitriptyline), insulin, phenobarbital, phenytoin, prednisone, prednisolone, spironolactone, theophylline, and warfarin
• If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian.

Overdosing?

Contact your veterinarian immediately if pet receives more than the prescribed amount.

What else should I know?

Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.

As with all prescribed medicines, mitotane should only be given to the pet for which it was prescribed. It should be given only for the condition for which it was prescribed.

This is just a summary of information about mitotane. If you have any questions or concerns about mitotane or the condition it was prescribed for, contact your veterinarian.
 

Mitotane
(o,p-DDD, Lysodren)

Common Drug Name
Mitotane, o,p-DDD

Common Brand Names
Lysodren
No generic products are available.

Storage
Store at room temperature in a tight, light resistant, childproof container.

Uses
Mitotane is used in the treatment of hyperadrenocorticism (Cushing’s disease), most commonly in dogs and ferrets.

Dose and Administration
Always follow the dosage instructions provided by your veterinarian.  If you have difficulty giving the medication, contact your veterinarian.
Mitotane is given orally, usually with an oily or fatty food to increase absorption. Follow your veterinarian’s directions as to how it should be given
Mitotane is usually given at high doses for the first 1-2 weeks, and then the dose is lowered under the direction of the veterinarian.
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give 2 doses at once.
This medication should only be given to the pet for whom it was prescribed.

Possible Side Effects
May see lethargy, weakness, lack of appetite, vomiting, diarrhea, incoordination, or depression. Your veterinarian may prescribe glucocorticoids if these signs are observed.
May cause liver damage, which could result in loss of appetite and jaundice (yellowing of the gums, skin, or eyes).
Consult your veterinarian if you notice any of the above side effects.
As the mitotane becomes effective, you will notice a decrease in your pet’s food and water intake, and urination. 
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Precautions
Not for use in animals hypersensitive (allergic) to it or drugs similar to it.
Do not use in pregnant or lactating animals (female animals nursing their young). If the mother is receiving mitotane, place the offspring on milk replacer after they have received the colostrum (first milk immediately after birth).
Switching from a tablet form to oral liquids or powders, or giving a crushed tablet could dramatically increase the amount of mitotane that enters the blood stream. Do not switch forms unless under the direct supervision of your veterinarian.
Use with caution in animals with liver or kidney disease. May cause liver changes especially with long-term therapy or if the animal had preexisting liver disease.
Your veterinarian may prescribe gluco­corticoids, such as prednisone, to use during times of stress such as travel, introduction of a new pet, new baby, household guests, surgery, or illness.

Human Precautions
CAUTION: Pregnant women or women trying to get pregnant should not handle this medication.
Wear gloves when handling this medication. Wash hands after handling the medication. It can be very toxic.
Do not allow mitotane to enter the environment through the soil or water. Any leftover drug should be returned to your veterinarian for disposal.

Drug, Food and Test Interactions
Consult your veterinarian before using mitotane with any other medications, including vitamins and supplements, prednisone, prednisolone, barbiturates, warfarin, phenobarbital, or spironolactone, since interactions may occur.
May see an increase in depressant effects if given with other central nervous system (CNS) depressants.
Starting mitotane therapy may cause a  rapid change in the insulin requirement of diabetic animals.

Signs of Toxicity/Overdose
An overdose or toxicity would hypo­adrenocorticism (Addison’s disease), the opposite of hyperadrenocorticism. Hypo­adrenocorticism can be life threatening if not treated. The signs include loss of appetite, vomiting, diarrhea, weakness, depression, or lethargy. 
If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.
Keep this and all other medications out of the reach of children and pets.

This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times.  Always consult your own veterinarian for specific advice concerning the treatment of your pet.


 

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