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Acepromazine Maleate

Acepromazine Maleate by VetOne

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Acepromazine Maleate

Generic Name:


General Description:
Acepromazine is commonly used in dogs and cats as a sedative and as a pre-anesthetic agent. It may be used to prevent vomiting, alleviate various behavior issues, reduce itching and more. This medication should only be given to the pet which it was prescribed. Acepromazine is available in 5 mg, 10 mg and 25 mg tablets.

What is this drug?
Acepromazine is a neuroleptic agent; used as a tranquillizer in pets
Acepromazine can be given by mouth, or at your veterinarian's as an injection

Reasons for prescribing:
Used to help sedate animals for minor procedures (grooming, veterinary examination, treatment, minor surgical procedures, etc.)
Used to prevent nausea/motion sickness
To alleviate fear, nervousness, excessive vocalization
Used as a pre-anesthetic agent before an animal is anesthetized
To keep heart rhythm stable under certain conditions
To alleviate itching due to skin irritations
What dogs/cats should not take this medication?
Use with caution in Boxers and Sighthounds (greyhounds, whippets, wolfhounds, etc.) who are sensitive
Use with caution in pets with history of liver disease or blood abnormalities
Those in shock, or animals with tetanus or suffering strychnine poisoning
Pets exposed to organophosphate insecticides, including flea collars, within a month of using acepromazine
Pets currently using other depressants
Pets with high blood pressure or other circulation problems
Pets with seizure disorders
Geriatrics or those in a weakened state
Pregnant or nursing animals
Pets known to have had an allergic reaction to acepromazine or other phenothiazines
Acepromazine tablets are absorbed differently by different animals. Some pets will appear heavily sedated, while others will be hardly tranquilized. The dose may need to be individualized by your veterinarian based upon your pet's response.

Most effective if given when the animal is not stimulated or excited.

Acepromazine's effects are expected to last 6-8 hours.

Read and follow the label carefully.

Give the exact amount prescribed and only as often as directed.

What if dose is missed?

If a dose is missed, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.

What to tell/ask veterinarian before giving medication?
Talk to your veterinarian about:

When will your pet need to be rechecked
What tests may need to be performed prior to and during treatment with this drug
Risks and benefits of using this drug

Tell your veterinarian about:
If your pet has experienced side-effects on other drugs/products
If your pet has experienced digestive upset now or ever
If your pet has experienced liver or kidney disease now or ever
If your pet has experienced any other medical problems or allergies now or ever
All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
If your pet is pregnant or nursing or if you plan to breed your pet
Storage and Warnings:
Store acepromazine in a tight, light resistant, childproof container in a cool, dry place at room temperature away from heat and direct sunlight.

People should not take this product. Keep this and all medication out of reach of children and pets.

Call your physician immediately if you accidentally take this product.

Potential side effects:
Pet's third eyelid will rise partly over eye. This is a normal reaction to the drug and not harmful to the pet.
Because the drug depresses the central nervous system, the pet will experience sedation, depression, lack of coordination, low blood pressure, slower heart rate and breathing
Rarely, some pets show aggressive behavior (aggression, biting, chewing, nervousness)
Possible thermoregulation difficulties; pet may become too hot or too cold
Pale gums
Urine may turn pink or red-brown
If you notice anything unusual, contact your veterinarian
Can this drug be given with other drugs?
Yes, but possible interactions may occur with aminoglycoside antibiotics, antacids, atropine, barbiturates, bismuth subsalicylate compounds, epinephrine, kaolin-pectin, organophosphate insecticides (including flea collars and many products used outdoor flea treatment products), procaine, propranolol, phenylpropanolamine, phenytoin, quinidine and tricyclic antidepressants.

If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian
Contact your veterinarian immediately if pet eats more than the prescribed amount.

What else should I know?
Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.

As with all prescribed medicines, acepromazine should only be given to the dog/cat for which it was prescribed. It should be given only for the condition for which it was prescribed.

This is just a summary of information about acepromazine. If you have any questions or concerns about acepromazine or for the condition it was prescribed, contact your veterinarian.


Common Drug Name

Common Brand Names
Promace and Aceproject
Generic products are available.

Store at room temperature in a tight, light resistant, childproof container. Protect the injectable liquid from freezing.

Acepromazine is a tranquilizer used to sedate animals for minor procedures (e.g., nail trims) and prevent vomiting due to motion sickness. It is also used prior to anesthesia, and helps to keep the heart rhythm stable under certain conditions. It is not a pain reliever. It is used in dogs, cats, and horses, as well as other species. 

Dose and Administration
Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give 2 doses at once.
This medication should only be given to the pet for whom it was prescribed.

Possible Side Effects
May see droopy eyelids with the third eyelid more exposed, incoordination, or slower heart rate and breathing.
Urine may appear pink or reddish brown following use of acepromazine.
May cause aggressiveness and stimulation in some animals. 
Consult your veterinarian if you notice any of the above side effects
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Not for use in animals hypersensitive (allergic) to it or other phenothiazines.
Use with caution in debilitated or geriatric animals and those with liver or heart disease.
Do not use in pregnant or lactating animals (female animals nursing their young) unless benefits outweigh the risks.
Do not use in animals with hypovolemia (low blood volume), anemia, or shock.
Do not use in animals with tetanus or strychnine toxicity. 
May cause seizures. Do not use with animals known to have seizures or are having medical procedures known to cause seizures (e.g., myelograms).
When used to aid in restraint, the sedative effect can be overridden and the animal may bite or jump unexpectedly. 
Acepromazine is an inappropriate medica­tion for the treatment of aggression since it can make aggressive animals less predict­able, and can interfere with training. 
Does not provide any pain relief. 
Giant breeds, greyhounds, and boxers may be more sensitive to its effects; terriers may be less sensitive.
Effects may last 6-8 hours, and results may not be consistent when given orally.
Consult with your veterinarian regarding the physical examinations and laboratory testing necessary prior to and during treatment with acepromazine.  

Drug, Food, and Test Interactions
Consult your veterinarian before using acepromazine with vitamins, supplements, atropine, central nervous system (CNS) depressant drugs (such as barbiturates, narcotics,  and antidepressants), organophosphate dewormer or insecticide, kaopectate, Pepto-Bismal, other antidiarrheal mixures, antacids, propranolol, and epinephrine.
May have an adverse heart reaction if used with quinidine.
Phenytoin levels and procaine activity may be increased if used with acepromazine. 

Signs of Toxicity/Overdose
May see excessive sedation, slowed breathing and heart rates, pale gums, unsteady movements, unconsciousness, low blood pressure, or seizures.
If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.
Keep this and all other medications out of the reach of children and pets.
Causes low blood pressure and inability to maintain proper body temperature. 

This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times.  Always consult your own veterinarian for specific advice concerning the treatment of your pet.



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