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Vetoryl by Dechra Veterinary Products

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Vetoryl® Capsules (trilostane)

Generic Name:


 General Description:

A short-acting adrenocortical suppressant for oral use in dogs. Trilostane blocks the adrenal gland from making too many steroids. Although steroids are important for various functions of the body, too much can cause problems.

 What is this drug?
  • An adrenocortical suppressant
  • Given by mouth
 Reasons for prescribing:
  • For the treatment of both pituitary-dependent or adrenal-dependent hyperadrenocorticism (Cushing's disease) in dogs
  • Trilostane is a treatment but not a cure for this condition
 What dogs/cats should not take this medication?
  • This product is for dogs only
  • Use with caution in pets with anemia, liver or kidney disease
  • Do not use in pregnant dogs
  • Safe use has not been established in nursing dogs or breeding males
  • If your pet has had an allergic reaction to trilostane or like products before

Read and follow the label carefully.

Give the exact amount prescribed and only as often as directed. Give trilostane once daily with the morning meal. This will make it easier to perform future blood testing.

Do not open or divide capsules.

Baseline blood work to assess your pet's health before starting this drug is recommended. Periodic blood work to monitor its effect is also advised if long-term therapy is necessary. Dose adjustments will be made based upon the blood results and an assessment of how your dog is responding clinically.

Most dogs remain on trilostane for the remainder of their life.

Call ahead for refills.

 What if a dose is missed?

If a dose is missed, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.

 What to tell/ask veterinarian before giving medication?

Talk to your veterinarian about:

  • When will your pet need to be rechecked
  • What tests may need to be performed prior to and during treatment with this drug
  • What are the risks and benefits of using this drug

Tell your veterinarian about:

  • If your pet has experienced side-effects on other drugs/products
  • If your pet has experienced digestive upset now or ever
  • If your pet has experienced anemia, liver or kidney disease now or ever
  • If your pet has experienced diabetes or any other medical problems or allergies now or ever
  • All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
  • If your pet is pregnant or nursing or if you plan to breed your pet
 Storage and Warnings:

Store in a childproof container at room temperature away from heat and direct sunlight.

Keep this and all medication out of reach of children and pets. This medication is potentially harmful to humans. Do not handle this product if you are pregnant or trying to conceive. Wash your hands well after handling.

Call your physician immediately if you accidentally take this product.

 Potential side effects:
  • This medication is usually well tolerated by dogs
  • Most common effects: lethargy, weakness, loss of appetite in first few days, vomiting and diarrhea
  • More serious effects: severe depression, hemorrhagic diarrhea, collapse, hypoadrenocortical crises or adrenal necrosis/rupture, death
  • Rare cases of acute death or hypoadrenocorticism
  • If you notice anything unusual, stop therapy and contact your veterinarian
 Can this drug be given with other drugs?
  • Yes, but possible interactions may occur with ACE inhibitors and potassium-sparing diuretics (ex. spironolactone).
  • An interval of at least one month should be observed after stopping the administration of mitotane and starting trilostane. Close monitoring of adrenal function is advised.
  •  If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian.

Contact your veterinarian immediately if pet eats more than the prescribed amount.

 What else should I know?

Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.

As with all prescribed medicines, trilostane should only be given to the pet for which it was prescribed. It should be given only for the condition for which it was prescribed.

 This is just a summary of information about trilostane. If you have any questions or concerns about trilostane or the condition it was prescribed for, contact your veterinarian.


Common Drug Name

Common Brand Names
Generic products are not available.

Store at room temperature in a tight, light resistant, childproof container.

Trilostane is used for the treatment of hyperadrenocorticism, also known as Cushing?s Disease, in dogs. Trilostane is a treatment for this disease ? it is not a cure.

Dose and Administration
Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.
Give with food unless otherwise directed by your veterinarian.
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give 2 doses at once.
This medication should only be given to the pet for whom it was prescribed.

Possible Side Effects
Potential side effects include an unexpected decrease in appetite, vomiting, diarrhea, and lethargy. Rarely, may see more serious adverse effects including severe depression, bloody diarrhea, collapse, or other severe reactions, possibly leading to death. If you think your dog is having a reaction to trilostane, discontinue use and consult your veterinarian immediately.
The signs of hyperadrenocorticism include increased appetite, increased drinking and increased urination. As trilostane controls the effects of hyperadrenocorticism, the signs of this disease should decrease.
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Not for use in animals hypersensitive (allergic) to trilostane.
Do not use in pregnant animals. The safe use of this drug has not been determined in lactating dogs (females nursing their young) or dogs intended for breeding.
Do not use in animals with primary liver disease or certain kidney diseases. 
The use of trilostane may result in the development of hypoadrenocorticism (Addison?s Disease) and/or corticosteroid withdrawal syndrome.
Consult with your veterinarian regarding the physical examinations and laboratory testing necessary prior to and during treatment with trilostane.

Human Precautions
Wear gloves and/or wash hands after use.
Do not open, empty or divide capsules. 
Do not handle capsules if you are pregnant, or may become pregnant.
In cases of human accidental ingestion, seek medical advice immediately and take the labeled container with you.

Drug, Food and Test Interactions
Notify your veterinarian of any other medications, including vitamins and supplements your pet is taking while your pet is receiving trilostane.
Consult your veterinarian before using trilostane with ACE inhibitors such as enalapril; potassium sparing diuretics such as spironolactone; ketoconazole; or potassium supplements since interactions may occur.
Wait at least one month from discontinuing mitotane (o,p?-DDD) treatment before starting treatment with trilostane. 

Signs of Toxicity/Overdose
May see lethargy, weakness, vomiting, or collapse. If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.
Keep this and all other medications out of the reach of children and pets.

This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times.  Always consult your own veterinarian for specific advice concerning the treatment of your pet.


Customer Reviews

Average Customer Rating: (Excellent) based on 1 review
Write an online review and share your thoughts with other customers.

231 of 465 found the following review helpful:
5 Stars Vetoryl has worked well for my dog
by a member from Woodinville, WA on Feb 6, 2016
  My Beagle was diagnosed with Cushing's disease about 3 years ago and he is now 14. I will first add that he has a milder case of the disease with no tumors. That said, he has had no bad reactions to the Vetoryl and other than still drinking lots of water and always being hungry, the symptoms have not gotten worse. This drug only alleviates the symptoms and does not cure the disease but it has worked well for our situation. It is expensive and there needs to be a lot of veterinary assistance but keeping my dog comfortable as he ages, and around a bit longer, is certainly worth it to me.
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